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Detailed Duloxetine dosage information for adults, the elderly and children. Includes dosages for Depression, Pain, Chronic Pain and more; plus renal, liver and dialysis adjustments. 634 medications are known to interact with duloxetine. Includes gabapentin, omeprazole, sertraline. A Moderate Drug Interaction exists between duloxetine and gabapentin. View detailed information regarding this drug interaction. See the list of drugs that interact with Duloxetine. Includes information on severity of interaction and the level of evidence for it. The following applies to the ingredients: Gabapentin and Duloxetine (found in Cymbalta) Treatment with DULoxetine may occasionally cause blood sodium levels to get too low, a condition known as hyponatremia, and using it with some anticonvulsants can increase that risk. For most individuals, it is safe to take gabapentin and Cymbalta (duloxetine) together. In fact, they are commonly used in combination to treat certain conditions, like neuropathy (nerve-type pain). There are some precautions, that I list below, but generally, they are of low risk. Duloxetine, sold under the brand name Cymbalta among others, [1] is a medication used to treat major depressive disorder, generalized anxiety disorder, obsessive–compulsive disorder, fibromyalgia, neuropathic pain, central sensitization, and other types of chronic pain. [9][10] It is taken by mouth. [9] Duloxetine is a serotonin–norepinephrine reuptake inhibitor (SNRI). [11] The precise Mixing Duloxetine with MAOIs can be highly dangerous, potentially leading to serotonin syndrome, a rare but life-threatening drug side effect of serotonergic substances. Symptoms of serotonin syndrome can emerge within hours and, if not treated, can be fatal. These symptoms include but are not limited to: There are many medications, supplements, and beverages (like alcohol) that can interact with duloxetine. These interactions can cause side effects, some of which can be serious. It’s important to give your healthcare provider an accurate medication list with everything you’re taking. A Moderate Drug Interaction exists between Cymbalta and gabapentin. View detailed information regarding this drug interaction. In addition, DULoxetine can cause seizures in susceptible patients, which may reduce the effectiveness of medications that are used to control seizures such as gabapentin. Talk to your doctor if you have any questions or concerns. Compared to TCAs and first-generation anticonvulsants, newer drugs like Duloxetine, Gabapentin, and pregabalin successfully cure pain with more tolerable side-effect profiles. Duloxetine is also sometimes used to treat stress urinary incontinence (leakage of urine during physical activity such as coughing, sneezing, laughing, and exercise) in women. Talk to your doctor about using this medication to treat your condition. This medication may be prescribed for other uses; ask your doctor or pharmacist for more information. Description Duloxetine is used to treat depression and anxiety. It is also used for pain caused by nerve damage associated with diabetes (diabetic peripheral neuropathy). Duloxetine is also used to treat fibromyalgia (muscle pain and stiffness) and chronic (long-lasting) pain that is related to muscles and bones. Duloxetine belongs to a group of medicines known as selective serotonin and The duloxetine is for severe depression caused by chronic pain and the gabapentin is for restless leg syndrome and nerve pain. They both help a lot especially gabapentin. Drug interactions are reported among people who take Duloxetine hydrochloride (duloxetine hydrochloride) and Gabapentin (gabapentin). Common drug interactions include pneumonia among females and hyperhidrosis among males. Duloxetine (Cymbalta) is a drug used to treat fibromyalgia and nerve pain. Learn about side effects, drug interactions, dosages, warnings, and more. Generic name: duloxetine [ du-LOX-e-teen ] Brand names: Cymbalta, Drizalma Sprinkle, Irenka Dosage form: oral delayed release capsule (20 mg; 30 mg; 40 mg; 60 mg) Drug class: Serotonin-norepinephrine reuptake inhibitors Medically reviewed by Philip Thornton, DipPharm. Last updated on Mar 3, 2025. Uses Warnings Before taking Dosage Side effects Interactions FAQ What is duloxetine? Duloxetine is Learn about duloxetine oral capsule’s side effects, how it's taken, and more. It's a generic prescription drug used for various conditions, including depression. Compare Duloxetine vs Gabapentin head-to-head with other drugs for uses, ratings, cost, side effects and interactions.
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