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Few direct head-to-head comparisons have been conducted between drugs for the treatment of diabetic peripheral neuropathic pain (DPNP). Approved or recommended drugs in this indication include duloxetine (DLX), pregabalin (PGB), gabapentin (GBP) and Duloxetine is also used in adults to treat nerve pain caused by diabetes (diabetic neuropathy), or chronic muscle or joint pain (such as low back pain and osteoarthritis pain). Some brands of duloxetine are also used to treat fibromyalgia (a chronic pain disorder). Drizalma is for treating fibromyalgia only in adults. Duloxetine, pregabalin, and duloxetine plus gabapentin for diabetic peripheral neuropathic pain manage-ment in patients with inadequate pain response to gabapentin: An open-label, randomized, noninferiority comparison. That’s the situation for millions of people who suffer from idiopathic sensory polyneuropathy. The term “idiopathic” means that no cause can be identified; “sensory” refers to the type of nerve, in this case those carrying nerve signals such as pain or temperature; “poly” means “many” and “neuropathy” means nerve disease. This meta-analysis aims to compare the efficacy and safety of duloxetine and gabapentin in the treatment of diabetic peripheral neuropathic pain (DPNP) and therefore to provide evidence-based medicine for clinical treatment. A meta-analysis of 3 RCTs found no significant difference in pain intensity and other outcomes between gabapentin and duloxetine for PDPN. The study suggests that clinicians can choose the drug based on price and side effects. This meta-analysis aims to compare the efficacy and safety of duloxetine and gabapentin in the treatment of diabetic peripheral neuropathic pain (DPNP) and therefore to provide evidence-based medicine for clinical treatment. Patients were randomized to duloxetine monotherapy (n=138), pregabalin monotherapy (n=134), or a combination of duloxetine and gabapentin (n=135). The primary objective was a noninferiority comparison between duloxetine and pregabalin on improvement in the weekly mean of the diary-based daily pain score (0- to 10-point scale) at end point. Discussion Both duloxetine and pregabalin have shown a significant reduction in neuropathic pain over a period of 12 weeks. Duloxetine showed a higher reduction in pain as compared to pregabalin and the differences were statistically significant. While this study, to the best of our knowledge, is the first local study to compare pregabalin and duloxetine for pain reduction in diabetic Gabapentin was first 2- ligand to receive approval for treatment of neuropathic pain. Its half-life is 6–8 h, consequently drug is typically administered three times daily.19 Dosing regimen with titration up to 1800 mg and maximum upper dose of 3600 mg is recommended in painful diabetic polyneuropathy.20 Duloxetine (Cymbalta) is a drug used to treat fibromyalgia and nerve pain. Learn about side effects, drug interactions, dosages, warnings, and more. Gabapentin (Neurontin) and Duloxetine (Cymbalta) are both prescription medications, but they are used for different conditions and belong to different drug classes. Gabapentin is an antiepileptic used to treat certain seizures and nerve pain, while Duloxetine is an SNRI (serotonin and norepinephrine reuptake inhibitor) used to treat depression, anxiety, and various types of long-term pain Discover the differences between gabapentin or duloxetine for nerve pain, fibromyalgia, and diabetic neuropathy. Learn about dosing, side effects, pros and cons, and patient experiences. Compare Duloxetine and Gabapentin for treating anxiety, depression, and nerve pain. Which medication is more effective and has fewer side effects? Description Duloxetine is used to treat depression and anxiety. It is also used for pain caused by nerve damage associated with diabetes (diabetic peripheral neuropathy). Duloxetine is also used to treat fibromyalgia (muscle pain and stiffness) and chronic (long-lasting) pain that is related to muscles and bones. Duloxetine belongs to a group of medicines known as selective serotonin and Compare Gabapentin vs Duloxetine head-to-head with other drugs for uses, ratings, cost, side effects and interactions. Gralise (gabapentin) and Cymbalta (duloxetine) are used to treat different types of neuralgia (nerve pain). Gabapentin is used postherpetic neuralgia from herpes zoster (nerve damage from shingles) and to treat seizure disorders. Cymbalta is used to treat pain associated with diabetic peripheral neuropathy, depression, generalized anxiety disorder, fibromyalgia, and chronic musculoskeletal pain. Background Few direct head-to-head comparisons have been conducted between drugs for the treatment of diabetic peripheral neuropathic pain (DPNP). Approved or recommended drugs in this indication include duloxetine (DLX), pregabalin (PGB), gabapentin (GBP) and amitriptyline (AMT). We conducted an indirect meta-analysis to compare the efficacy and tolerability of DLX with PGB and GBP in DPNP Compare Duloxetine vs Gabapentin head-to-head with other drugs for uses, ratings, cost, side effects and interactions. Compare Cymbalta vs Gabapentin head-to-head with other drugs for uses, ratings, cost, side effects and interactions.
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