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Gabapentin is an effective prophylactic agent for patients with migraine. In addition, gabapentin appears generally well tolerated with mild to moderate somnolence and dizziness. KEY POINTS Oral medications traditionally used for the prevention of migraine and known to be effective include anti-epileptic, β-blocker, antihypertensive and antidepressant drugs. OnabotulinumtoxinA (Botox) injection is indicated for prevention in patients with chronic migraine, as it has very few drug interactions or systemic or long-term adverse effects; however, it must be administered Off-label, gabapentin has been used in the treatment of migraine and other types of headache, including cluster and tension headaches. It shows potential as an option for those living with migraine and other headache disorders. Often known for its brand names Horizant, Neurontin, or Gralise, Gabapentin (GBT) is an anticonvulsant drug, but it’s sometimes used for migraine and headache prevention. Its original use is for seizure prevention for patients with epilepsy, or to alleviate the uncomfortable symptoms of shingles. What is Gabapentin, and how does it relate to migraine treatment? Gabapentin is a medication primarily used to treat seizures and nerve pain, but it’s being studied for its potential benefits in managing migraines. Gabapentin may be used alone or with other medications when necessary. The American Academy of Neurology (AAN) and the American Headache Society (AHS) do not list gabapentin as "effective" or "probably effective" for preventing migraines in their 2012 guidelines. Migraine headaches are a debilitating condition that affects approximately 1% of the US population. Goals of migraine prophylaxis include reduction in headache severity and frequency, improved Reviews and ratings for Gabapentin when used in the treatment of migraine. 121 reviews submitted with a 7.8 average score. Gabapentin is an antiepileptic drug that has shown promise in the prevention of migraines. Clinical trials indicate its effectiveness, yet the evidence remains mixed regarding its overall safety. Opioid analgesics are not recommended due to risks of medication overuse headaches and abuse. Evidence for acute migraine treatment medications is summarized in Table 3. This review considers the evidence for the efficacy and tolerability of the antiepileptic drugs gabapentin and pregabalin for preventing episodic migraine in adults. Recurrent migraines can be functionally disabling and can impair quality of life. The disabling nature of migraine headaches leads to frequent visits to outpatient clinics and emergency department facilities, causing significant health and financial burdens. Headaches fall in the top five causes of emergency department visits and the top twenty reasons for outpatient visits.[1] The overall Gabapentin has emerged as a valuable medication for migraine prevention and headache control. Its neurological approach to migraine treatment offers significant benefits to those suffering from chronic migraines. Compare risks and benefits of common medications used for Migraine. Find the most popular drugs, view ratings and user reviews. Gabapentin is a drug that’s approved to help prevent seizures in people with epilepsy and treat nerve pain from shingles. It’s also sometimes used off-label for migraine prevention. While there are several trials that support the efficacy of various drugs for migraine prophylaxis against placebo, there is limited evidence addressing the comparative safety and efficacy of these drugs. We conducted a systematic review and network meta-analysis to facilitate comparison between drugs for migraine prophylaxis. Alcohol can increase the nervous system side effects of gabapentin such as dizziness, drowsiness, and difficulty concentrating. Some people may also experience impairment in thinking and judgment. You should avoid or limit the use of alcohol while being treated with gabapentin. Gabapentin does not decrease the frequency of migraine headaches and is not recommended for prophylactic therapy. (Strength of Recommendation: B, based on inconsistent or Gabapentin is used "off-label" for migraine prevention and treatment, including migraines with or without aura, vestibular migraines. It reduces the frequency of headaches, pain intensity, and the use of symptomatic medications 1, 2. INTRODUCTION Migraine is a common episodic disorder, the hallmark of which is a disabling headache generally associated with nausea and/or light and sound sensitivity. The acute treatment of migraine in adults is reviewed here. Preventive treatment of migraine in adults is discussed separately. (See "Preventive treatment of episodic migraine in adults".) The pathophysiology, clinical
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