Five studies reported significant findings with increased risks of overall congenital anomalies, specific anomalies (nervous system, eyes, oro-facial clefs, urinary and genital system), miscarriage, stillbirth and specific neurodevelopmental outcomes after exposure to pregabalin during pregnancy. If you're trying to get pregnant or have become pregnant while taking gabapentin, it is recommended to take a high dose of folic acid (5mg a day). You can get this from your doctor or midwife. Gabapentin (Neurontin®) is mainly used to treat epilepsy and nerve pain, and to prevent migraine. What are the benefits of taking gabapentin in pregnancy? Gabapentin prevents epileptic seizures, which can be dangerous to the woman and also lead to pregnancy complications. Gabapentin is a pregnancy category C, which means risk cannot be ruled out. Gabapentin can be transmitted through human milk. It’s currently unknown how breast milk containing gabapentin affects newborns or even the milk production process. Consult your physician about breastfeeding while taking gabapentin. Does gabapentin affect female fertility? Gabapentin in pregnancy and the risk of adverse neonatal and maternal outcomes: A population-based cohort study nested in the US Medicaid Analytic eXtract dataset. Overview of the five pregnancy risk categories, established by the FDA to indicate the potential of a drug to cause birth defects if used during pregnancy. A study from the European Gabapentin Registry included prospective and retrospective data with a total of 51 outcomes and 44 live births of women with epilepsy and other disorders exposed to gabapentin during pregnancy. Gabapentin is a Pregnancy Category C drug and Animal studies suggest that it can harm an unborn child and therefore should be avoided during pregnancy. Is gabapentin safe during pregnancy? Learn about the potential risks and benefits of taking gabapentin while pregnant, and what you should discuss with your doctor. Pregnancy-related problems, such as preterm delivery (birth before week 37) or low birth weight (weighing less than 5 pounds, 8 ounces [2500 grams] at birth) have been reported in some studies looking at the use of gabapentin during pregnancy. 4,642 pregnancies with first trimester gabapentin exposure were identified (mean age of 28 years; 69% white). A reference group consisting of 1,744,447 unexposed pregnancies (mean age of 24 years; 40% white) was also identified. What are the benefits of taking gabapentin in pregnancy? Gabapentin prevents epileptic seizures, which can be dangerous to the woman and also lead to pregnancy complications. Gabapentin can also improve nerve pain which can severely affect quality of life. Despite the increasing number of patients receiving gabapentin prescriptions, little information is available on the safety of this medication during pregnancy. We therefore evaluated the association between the use of gabapentin exposure during pregnancy and the risk of a range of neonatal and maternal outcomes. T1 exposure was defined as pregnancies with at least one filled prescription for gabapentin during the first 90 days of pregnancy (starting from the date of LMP), independently of exposure to gabapentin later in pregnancy. While gabapentin (Neurontin) is now used in a wide variety of clinical settings — for epilepsy, pain management, restless leg syndrome, anxiety, and sleep disturbance – there is relatively little information regarding its reproductive safety. Most recently, a prospective study from researchers at the Motherisk program reports on the outcomes of 223 pregnancies exposed to gabapentin Limited observations have suggested an active transplacental transport of gabapentin, with accumulation in the fetus as a consequence. Gabapentin has been assigned to pregnancy category C. Animal studies have revealed evidence of fetotoxicity involving delayed ossification in several bones of the skull, vertebrae, forelimbs and hindlimbs. In this large population-based study, we did not find evidence for an association between gabapentin exposure during early pregnancy and major malformations overall, although there was some evidence of a higher risk of cardiac malformations. Maternal use of gabapentin, particularly late in pregnancy Pregnancy-related problems, such as preterm delivery (birth before week 37) or low birth weight (weighing less than 5 pounds, 8 ounces [2500 grams] at birth) have been reported in some studies looking at the use of gabapentin during pregnancy. This article summarizes the current literature regarding gabapentin use during pregnancy and related prenatal and neonatal exposure outcomes with special consideration for interactions between gabapentin and opioid use. Advice and warnings for the use of Gabapentin during pregnancy. FDA Pregnancy Category C - Risk cannot be ruled out
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