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Research shows that patients with six or more prescriptions for gabapentin, commonly used to treat lower back pain, were 29% more likely to be diagnosed with dementia and 85% more likely to be diagnosed with mild cognitive impairment within 10 years of their initial pain diagnosis. Abstract Risk of dementia following gabapentin prescription in chronic low back pain patients Introduction Gabapentin is widely used to treat chronic pain, but its association with cognitive decline and dementia remains unclear. This study examined whether gabapentin prescription is associated with dementia in adults with chronic low back pain. Methods We conducted a retrospective cohort study Gabapentin new users with normal cognition at the visit of gabapentin initiation (i.e., index visit) were included. New-users were matched on year of first enrollment and time of gabapentin initiation since enrollment to randomly select nonusers with replacement. Abstract Study objective To explore the association between gabapentin use and the risk of dementia in patients with chronic pain, considering the rising concerns of dementia in an aging population and the potential cognitive impacts of chronic pain management. The adverse events from gabapentin could be higher in older adults who have more polypharmacy, higher comorbidities, and decreased renal functions. Since gabapentin is also prescribed to treat behavioral and psychological symptoms of dementia (BPSD) 19, gabapentin could be widely prescribed in patients with dementia. Frequent use of common pain drug linked to increase in dementia and cognitive decline, study suggests. Gabapentin prescriptions for chronic back pain were linked to higher dementia and cognitive impairment risk. Risks were especially high for chronic back pain patients ages 35 to 64. The study Introduction Gabapentin, an anticonvulsant medication, has gained popularity in recent years for treating various conditions in elderly patients, including neuropathic pain, epilepsy, and behavioral symptoms associated with dementia. However, as with any medication, its use in older adults comes with unique considerations. This article delves into the safety profile of gabapentin for elderly New data suggest an association between gabapentin for chronic back pain and increased risk of cognitive impairment, although experts urge caution in drawing any firm conclusions. Objective: Previous studies have shown that gabapentin or pregabalin use is associated with cognitive decline. Herein, we aimed to evaluate the association between gabapentin or pregabalin use and the risk of dementia. Methods: In this Abstract Study objective To explore the association between gabapentin use and the risk of dementia in patients with chronic pain, considering the rising concerns of dementia in an aging population and the potential cognitive impacts of chronic pain management. Regular gabapentin use appeared to increase risk of dementia by 29% and mild cognitive impairment (MCI) by 85%, researchers reported July 10 in the journal Regional Anesthesia & Pain Medicine. What’s more, the risk was more than doubled in people normally considered too young to suffer from brain aging, those 18 to 64, results show. Receiving six or more prescriptions of the drug gabapentin for low back pain is associated with significantly increased risks of developing dementia and mild cognitive impairment (MCI)—29% and The authors describe the use of gabapentin in the treatment of 4 outpatients with dementia-associated agitation. On the basis of clinical case reports and the Overt Agitation Severity Scale, all 4 patients had reduced agitation with gabapentin. Three of 4 patients were successfully titrated to a full dose of 2,400mg/day. These findings suggest a possible role for gabapentin in the behavioral Complementing this formal systematic review, an illustrative case of a patient with BPSD in mixed Alzheimer's/vascular dementia, who appeared to derive benefits in terms of symptom control and functioning from the introduction of gabapentin titrated up to 3600 mg day -1 alongside other interventions, is presented. Gabapentin prescription in adults with chronic low back pain is associated with increased risk of dementia and cognitive impairment, particularly in non-elderly adults. Physicians should monitor cognitive outcomes in patients prescribed gabapentin. Frequent use of gabapentin for back pain may raise the risk of dementia by 29% and mild cognitive impairment by 85%, new study finds. A new study warns that gabapentin can significantly increase the risk of dementia and mild cognitive impairment in people taking it for chronic low back pain. ryanking999 – stock.adobe.com Conclusions Gabapentin prescription in adults with chronic low back pain is associated with increased risk of dementia and cognitive impairment, particularly in non-elderly adults. Physicians should monitor cognitive outcomes in patients prescribed gabapentin. Conclusion: Gabapentin initiation was significantly associated with deleterious neurocognitive changes among older adults with initially normal cognition. Further studies are needed to examine the risk/benefit of prescribing gabapentin in older adults.
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