INTRODUCTION We appreciate the thoughtful comments provided by Escribá and Hoyo 1 suggesting other therapeutic alternatives to clonazepam for the treatment of REM behavior disorder (RBD). Escribá and Hoyo highlight that gabapentin, pregabalin, and sustained-release melatonin may represent alternatives to clonazepam for the treatment of RBD. Although clonazepam is the first-line treatment for Gabapentin and REM Sleep: Effects, Benefits, and Potential Risks is a topic of particular interest to researchers. Some studies have found that gabapentin may increase slow-wave sleep, also known as deep sleep, which is crucial for physical restoration and cognitive function. Typically, taking gabapentin 1-2 hours before bedtime allows for its sleep-promoting effects to align with the desired sleep onset. Dosages generally start low, around 100-300 mg, and may be titrated up to 900 mg or more under medical supervision. Study Objectives:To evaluate the effects of single doses of gabapentin 250 and 500 mg on polysomnographic (PSG) and participant-reported sleep measures in a 5-h phase advance insomnia model.Methods:Adults reporting occasional disturbed sleep received Have you used Gabapentin for sleep or insomnia? If you’ve used gabapentin to treat a sleep disorder such as insomnia or to enhance sleep, be sure to share your experience in the comments section below. Gabapentin is a prescription medication that may help you sleep. That may be why it has been prescribed for people with insomnia, even though it is not approved for that use. However, gabapentin enacarbil (Horizant) has been approved by the Food and Drug Administration (FDA) to treat a sleep disorder called restless legs syndrome (RLS). One of the most common side effects of gabapentin is Explore the long-term effects of using gabapentin for sleep, including its impact on sleep architecture, potential benefits, and important considerations for extended use. Gabapentin, initially developed for seizure management, has found its niche in the realm of sleep aids. Its influence on neuropathic pain and anxiety suggests a potential benefit for those struggling with sleep issues as well. Types of Sleep Disorders Treated Gabapentin has been used to treat a variety of sleep disorders. The aim of this study was to systematically review the efficacy and tolerability of gabapentin in the treatment of sleep disturbance in patients with medical illness. PubMed was searched for randomized, double-blinded, placebo-controlled trials that Summary: Purpose: The older antiepileptic drugs (AEDs) have a variety of effects on sleep, including marked reduction in rapid-eye-movement (REM) sleep, slow-wave sleep (SWS), and sleep latency, and an increase in light sleep. The effects of the newer AEDs on sleep are unknown. Our purpose was to study the effect of gabapentin (GBP) on sleep. Gabapentin helps calm the nervous system, which is why it can affect sleep. While prescribed for insomnia, you may experience sleep disruptions when taking it. Gabapentin vs Doxepin for Sleep: Comparing Effectiveness and Side Effects provides a comparative analysis that can be helpful in understanding these options. For individuals with specific sleep-related conditions, such as sleep apnea, the relationship between gabapentin and their condition requires careful consideration. In conclusion, the intricate dance between gabapentin and sleep apnea presents both challenges and opportunities in the realm of sleep medicine and pain management. While gabapentin can offer significant benefits for various conditions, its use in patients with sleep apnea requires careful consideration and ongoing monitoring. By weighing the benefits against the potential risks, individuals can make informed decisions about using gabapentin for sleep. This ensures that it is utilized safely and appropriately in their treatment plans, addressing their specific sleep concerns while minimizing any adverse effects on their overall health and well-being. Abstract Purpose: The older antiepileptic drugs (AEDs) have a variety of effects on sleep, including marked reduction in rapid-eye-movement (REM) sleep, slow-wave sleep (SWS), and sleep latency, and an increase in light sleep. The effects of the newer AEDs on sleep are unknown. Our purpose was to study the effect of gabapentin (GBP) on sleep. Abstract Summary: Purpose: The older antiepileptic drugs (AEDs) have a variety of effects on sleep, including marked reduction in rapid-eye-movement (REM) sleep, slow-wave sleep (SWS), and sleep latency, and an increase in light sleep. The effects of the newer AEDs on sleep are unknown. Our purpose was to study the effect of gabapentin (GBP) on The potential benefits of gabapentin for sleep must be carefully weighed against its risks and side effects. For those considering gabapentin as a sleep aid, it’s crucial to consult with a healthcare professional who can provide personalized advice based on individual health history, sleep patterns, and specific sleep concerns. Given the observation of these normal reductions in slow wave sleep and often elevations in stage 1 sleep with age and the absence of clear sleep stage changes in insomnia, the functional significance and clinical relevance of drug related changes in stage 3–4 sleep still remains to be demonstrated. We found that regardless the type of sleep outcomes, gabapentin displayed stable treatment efficacy for sleep disturbance in patients with medical illness. However, when an average dose of approximately 1,800 mg/day was used, the risk of treatment discontinuation or drug withdrawal was relatively high. Participant-reported WASO and TST also showed significant treatment effects on both days. Gabapentin was associated with less %stage1 on Day 1, and greater %REM on Day 28, versus placebo. During home use, gabapentin resulted in significantly less participant-reported WASO and higher ratings of sleep quality.
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