Description Gabapentin enacarbil is used to treat moderate-to-severe primary Restless Legs Syndrome (RLS). RLS is a neurologic disorder that makes the legs feel uncomfortable. This results in an irresistible feeling of wanting to move your legs to make them comfortable. Gabapentin enacarbil is also used to manage a condition called postherpetic neuralgia, which is pain that occurs after Horizant (Gabapentin Enacarbil Extended-Release Tablets) may treat, side effects, dosage, drug interactions, warnings, patient labeling, reviews, and related medications including drug comparison and health resources. Generic Horizant Availability Last updated on Jun 11, 2025. Horizant is a brand name of gabapentin enacarbil, approved by the FDA in the following formulation (s): HORIZANT (gabapentin enacarbil - tablet, extended release;oral) Manufacturer: AZURITY Approval date: April 6, 2011 Strength (s): 600MG [RLD] Manufacturer: AZURITY Approval date: December 13, 2011 Strength (s): 300MG [RLD] Is there a HORIZANT® (gabapentin enacarbil) Extended-Release Tablets are indicated for the treatment of moderate-to-severe primary Restless Legs Syndrome (RLS) in adults. HORIZANT is not recommended for patients who are required to sleep during the daytime and remain awake at night. Gabapentin Enacarbil Generic name: Gabapentin Enacarbil [ gab-a-PEN-tin-en-a-KAR-bil ] Brand name: Horizant Drug class: Gamma-aminobutyric acid analogs Uses Before taking Warnings Dosage Side effects Overdose Uses of Gabapentin Enacarbil: It is used to treat restless leg syndrome. It is used to treat painful nerve diseases. It may be given to you for other reasons. Talk with the doctor. What Interactions Interaction Checker Enter a drug name to check for any interactions. and gabapentin enacarbil All Interactions Sort By: gabapentin enacarbil (Horizant, Gralise, Neurontin), a drug prescribed for the treating nerve damage from shingles, postherpetic neuralgia, and restless leg syndrome. Dizziness, somnolence, ataxia, fatigue, and drowsiness are the most common side effects. Horizant is a brand-name-only tablet that contains gabapentin enacarbil, a prodrug of gabapentin. Prodrugs like gabapentin enacarbil turn into the active form of the medication once they enter the body. Horizant is FDA-approved to treat nerve pain from shingles (postherpetic neuralgia) and restless leg syndrome (RLS) in adults. What is Gralise? Learn about Horizant (gabapentin enacarbil) usage and dosing. Read the latest news and reviews about the drug as well as potential side effects and popular alternatives. Horizant® is a unique form of gabapentin treatment for Postherpetic Neuralgia (PHN) and Restless Legs Syndrome (RLS). See Important Safety Information. Gabapentin enacarbil (Horizant (ER) (U.S.), Regnite (in Japan)) is an anticonvulsant and analgesic drug of the gabapentinoid class, and a prodrug to gabapentin. [1] It was designed for increased oral bioavailability over gabapentin, [2][3] and human trials showed it to produce extended release of gabapentin with almost twice the overall bioavailability, [4] especially when taken with a fatty Horizant (gabapentin enacarbil) is used to treat restless legs syndrome and nerve pain caused by the herpes virus. Includes Horizant side effects, interactions and indications. Gabapentin enacarbil, under the brand name Horizant, was introduced in the United States for the treatment of restless legs syndrome in April 2011 and was approved for the treatment of postherpetic neuralgia in June 2012. Common Brand Name (s): Horizant Common Generic Name (s): gabapentin enacarbil Pronunciation: GAB-a-pen-tin, ho-RI-zant Drug Classes: GABA analog Availability: prescription only, no generic Identification Summary Gabapentin enacarbil is a gabapentin prodrug used to treat Restless Legs Syndrome (RLS) and postherpetic neuralgia (PHN). Brand Names Horizant Compare Gabapentin vs Gabapentin Enacarbil head-to-head with other drugs for uses, ratings, cost, side effects and interactions. Lists the various brand names available for medicines containing gabapentin enacarbil. Find information on gabapentin enacarbil use, treatment, drug class and molecular formula. Horizant® (gabapentin enacarbil) Extended-Release Tablets are used to treat adults with moderate to severe primary Restless Legs Syndrome (RLS). See Important Safety Information. Brand names: Gralise, Horizant, Neurontin Drug class: GABA-mediated Anticonvulsants Medically reviewed by Drugs.com on Jun 10, 2024. Written by ASHP. Introduction Uses Dosage Warnings Interactions Stability FAQ Introduction Anticonvulsant; structurally related to the inhibitory CNS neurotransmitter GABA; also possesses analgesic activity. Gabapentin enacarbil is a prodrug of gabapentin. Uses Gabapentin Enacarbil is a prescription medication used for treating the symptoms of restless leg syndrome and postherpetic neuralgia. Gabapentin Enacarbil is available under the following different brand names: Horizant
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