Help your patients start and stay on Horizant ® with an easy-to-follow dose schedule 1 A unique gabapentin formulation, Horizant ® 600 mg contains ~313 mg of gabapentin. Horizant ® is not interchangeable with other gabapentin products, because of differing PK profiles. Learn more about how to dose Horizant ® for your patients with RLS and HORIZANT® (gabapentin enacarbil) Extended-Release Tablets are indicated for the treatment of moderate-to-severe primary Restless Legs Syndrome (RLS) in adults. HORIZANT is not recommended for patients who are required to sleep during the daytime and remain awake at night. HORIZANT® (gabapentin enacarbil) Extended-Release Tablets are indicated for the management of postherpetic neuralgia (PHN Gabapentin Extended-Release Tablets What is this medication? GABAPENTIN (GA ba pen tin) treats nerve pain. It works by calming overactive nerves in your body. Horizant™ will cost approximately $120 per month 7 as compared with generic gabapentin 600 mg tablets which cost approximately $31.00 per month 8 It is unclear how gabapentin enacarbil will compare with Gralise, an alternate gabapentin extended release formulation that was recently approved for the treatment of post-herpetic neuralgia. Dosage Forms Excipient information presented when available (limited, particularly for generics); consult specific product labeling. Tablet Extended Release, Oral: Horizant: 300 mg, 600 mg HORIZANT is administered orally. Each HORIZANT Extended-Release Tablet contains 300 mg or 600 mg of gabapentin enacarbil and the following inactive ingredients: colloidal silicon dioxide, dibasic calcium phosphate dihydrate, glyceryl behenate, magnesium stearate, sodium lauryl sulfate, and talc. 30 Tablets - NDC 53451-0101-1 - Horizant - ® (gabapentin enacarbil) extended-release tablets - 600 mg - Dispense the accompanying - Medication Guide to each patient. Each HORIZANT Extended-Release Tablet contains 366 300 mg or 600 mg of gabapentin enacarbil and the following inactive ingredients: colloidal 367 silicon dioxide, dibasic calcium phosphate dihydrate, glyceryl behenate, magnesium stearate, 368 sodium lauryl sulfate, and talc. In the current NDA, GSK proposed marketing of gabapentin enacarbil as extended release tablets containing 600 mg of the active ingredient (equivalent to 312 mg gabapentin). This medicine is used for the following purposes: nerve pain, restless leg syndrome, seizures. Brand Name (s): Horizant. Generic Name: Gabapentin. Detailed Gabapentin dosage information for adults and children. Includes dosages for Restless Legs Syndrome, Epilepsy and Postherpetic Neuralgia; plus renal, liver and dialysis adjustments. Each HORIZANT Extended-Release Tablet contains 300 mg or 600 mg of gabapentin enacarbil and the following inactive ingredients: colloidal silicon dioxide, dibasic calcium phosphate dihydrate, glyceryl behenate, magnesium stearate, sodium lauryl sulfate, and talc. 300 mg extended-release oral tablets 600 mg extended-release oral tablets How should I store Horizant? Horizant should be stored at room temperature, between 68 F to 77 F (20 C to 25 C). The recommended dosage is 600 mg orally 2 times a day. Therapy should be initiated at a dose of 600 mg orally in the morning for 3 days of therapy, then increased to 600 mg 2 times a day (1200 mg/day) on day four. Gabapentin enacarbil extended release tablets available under the trade name Horizant and gabapentin are not interchangeable. Discontinuation of HORIZANT When discontinuing HORIZANT, patients with RLS receiving 600 mg or less once daily can discontinue the drug without tapering. If the recommended dose is exceeded, the dose should be reduced to 600 mg daily for 1 week prior to discontinuation to minimize the potential of withdrawal seizure. Therapy should be initiated at a dose of 600 mg orally in the morning for 3 days of therapy, then increased to 600 mg twice daily (1,200 mg/day) on day four. Gabapentin enacarbil extended release tablets available under the trade name Horizant (R) and gabapentin are not interchangeable. Usual Adult Dose for Restless Legs Syndrome: Horizant (gabapentin enacarbil) is an extended release tablet used to treat restless legs syndrome and for the pain from having shingles (postherpetic nerve pain). Generic brands of gabapentin capsules, USP are used for postherpetic nerve pain and for add on therapy for partial onset seizures in patients 3 years and older Warnings gabapentin ER 600 mg tablet,extended release 24 hr The photos shown are samples only Not all photos of the drug may be displayed. Your medication may look different. If you have questions, ask your pharmacist. close popup Chen C, Cowles VE, Hou E. Pharmacokinetics of gabapentin in a novel gastric-retentive extended-release formulation: comparison with an immediate-release formulation and effect of dose escalation and food. Objective: Gabapentin immediate release (GBP-IR), gabapentin gastric retentive (GBP-GR), and the prodrug gabapentin enacarbil extended release formulation (GEn) have been approved for management of postherpetic neuralgia (PHN) in adults. This is the
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