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Abstract Introduction: Chemotherapy-induced peripheral neuropathy (CIPN) affects patients' quality of life and treatment effectiveness. Gabapentinoids, like gabapentin and pregabalin, are often used for CIPN treatment, but their efficacy and safety remain uncertain. This study reviews and analyses randomised controlled trial data on this topic. Efficacy of gabapentin in the management of chemotherapy-induced peripheral neuropathy: a phase 3 randomized, double-blind, placebo-controlled, crossover trial (N00C3). On the basis of these data, a multicenter, double-blind, placebo-controlled, crossover, randomized trial was conducted to evaluate the effect of gabapentin on symptoms of chemotherapy-induced peripheral neuropathy (CIPN). Chemotherapy-Induced Peripheral Neuropathy Treatments A literature review and discussion on medication management and emerging neuromodulation strategies for treating CIPN. Compared with the control group, gabapentin therapy led to a statistically significant better response in patients of each baseline neurotoxicity group. Conclusions. Gabapentin monotherapy seems to be well tolerated and useful for the management of chemotherapy-induced neuropathic pain. Gabapentin can help relieve nerve pain in some people with postherpetic neuralgia (nerve pain after shingles) and peripheral diabetic neuropathy (nerve pain in the feet in people with diabetes). A Cochrane review reported that 3 to 4 patients out of every 10 with either of these conditions experienced at least a 50% reduction in pain intensity when prescribed gabapentin at dosages of 1800mg Eight-week, multimodal exercise counteracts a progress of chemotherapy-induced peripheral neuropathy and improves balance and strength in metastasized colorectal cancer patients: a randomized controlled trial. Support Care Cancer 2018; 26:615. An overview of neurologic complications with platinum and non-platinum chemotherapy drugs, and recommendations for dose modification for platinum and non-platinum chemotherapeutic drugs when neuropathy develops during therapy are provided elsewhere. With the 1 older placebo-controlled clinical trial that showed no benefit for gabapentin for the treatment of chemotherapy-induced peripheral neuropathy, 66 2 subsequent trials investigating pregabalin as an agent to prevent chemotherapy-induced neuropathy (1 for paclitaxel 43 and 1 for oxaliplatin [ClinicalTrials.gov Identifier: NCT00380874 Gabapentin treats seizures by decreasing excitement in the brain and has been studied for its effect in patients with cancer who have neuropathic pain or symptoms of peripheral neuropathy. It also has been studied for its effect on anxiety and hot flashes. When peripheral neuropathy occurs due to chemotherapy treatment, it is termed Chemotherapy-induced peripheral neuropathy (CIPN) [1], [2], [5]. CIPN is a frequent adverse effect of anticancer agents most commonly presenting with sensory symptoms more than motor symptoms in a symmetrical “glove and stocking” distribution [3], [4], [5], [6]. Studies have shown that the long-term effects of using Gabapentin can reduce the need for high doses of opioids, as its analgesic effects target neuropathic nerve damage resulting from cancer treatment. Efficacy of gabapentin in the management of chemotherapy-induced peripheral neuropathy: a phase 3 randomized, double-blind, placebo-controlled, crossover trial (N00C3). The aim of our study was to assess the presence of chemotherapy-induced peripheral neuropathy in ovarian cancer patients treated with first-line paclitaxel and carboplatin chemotherapy and evaluate the effectiveness of gabapentin in treatment of this condition. When peripheral neuropathy occurs due to chemotherapy treatment, it is referred to as chemotherapy-induced peripheral neuropathy (CIPN). Typically, symptoms are sensory rather than motor and include reduced feeling and heightened sensitivity to The primary care clinician diagnosed chemotherapy-induced peripheral neuropathy (CIPN) and prescribed gabapentin, 100 mg, capsules thrice daily. At an appointment 4 weeks later, he reported feeling drowsy and tired. The CIPN symptoms were unchanged. Gabapentin treatment was discontinued. Gabapentin monotherapy seems to be well tolerated and useful for the management of chemotherapy-induced neuropathic pain. KEYWORDS: gabapentin, peripheral neuropathy, chemotherapy-induced peripheral neuropathy, taxanes, paclitaxel, cisplatin, carboplatin, vinca alkaloids, neurotoxi-city, pain. P eripheral neuropathy is a common complication of several classes of chemotherapeutic agents including taxanes (paclitaxel Compared with the control group, gabapentin therapy led to a statistically significant better response in patients of each baseline neurotoxicity group. Conclusions. Gabapentin monotherapy seems to be well tolerated and useful for the management of chemotherapy-induced neuropathic pain. Abstract Cancer diagnosis and treatment are drastic events for patients and their families. Besides psychological aspects of the disease, patients are often affected by severe side effects related to the cancer itself or as a result of therapeutic interventions. Particularly, chemotherapy-induced peripheral neuropathy (CIPN) is the most prevalent neurological complication of oral or
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