Regular gabapentin use appeared to increase risk of dementia by 29% and mild cognitive impairment (MCI) by 85%, researchers reported July 10 in the journal Regional Anesthesia & Pain Medicine Therapeutics Letter 75 examines new evidence from unpublished trials on the use of gabapentin for pain. Conclusions and recommendations Misleading promotion pushed gabapentin to blockbuster status; scientific evidence suggests gabapentin has a minor role in pain control. Gabapentin reduces neuropathic pain by < 1 point on a 0-10 point scale and benefits about 15% of carefully selected patients The study found adults taking gabapentin for chronic lower back pain faced a 29 per cent increased risk of dementia and an 85 per cent higher risk of mild cognitive impairment within a decade, compared to back pain sufferers not prescribed the drug. Gabapentin prescription in adults with chronic low back pain is associated with increased risk of dementia and cognitive impairment, particularly in non-elderly adults. Physicians should monitor cognitive outcomes in patients prescribed gabapentin. Anti-seizure medications used to treat chronic nerve pain include gabapentin (Gralise, Neurontin, Horizant) and pregabalin (Lyrica). These medications treat the burning pain of shingles, known as postherpetic neuralgia. What are the effects of nonopioid drugs on pain, function, and quality of life in patients with specific types of chronic pain, and what are the adverse events related to these drugs? Introduction Gabapentin is widely used to treat chronic pain, but its association with cognitive decline and dementia remains unclear. This study examined whether gabapentin prescription is associated with dementia in adults with chronic low back pain. Methods We conducted a retrospective cohort study using the TriNetX national database of de-identified patient records from 2004 to 2024 Gabapentin is widely used to treat chronic pain, but its association with cognitive decline and dementia remains unclear. This study examined whether gabapentin prescription is associated with dementia in adults with chronic low back pain. This topic will discuss an approach to pharmacologic management based on the type of pain and an overview of drug choices. Graded treatment recommendations can be found in treatment topics for specific chronic pain conditions (eg, chronic back pain, postherpetic neuralgia, fibromyalgia). Gabapentin is frequently used off-label for: Neuropathy caused by other etiologies such as chronic regional pain syndrome (CRPS), cancer, multiple sclerosis, phantom limb pain, HIV Gabapentin at doses of 1800 mg to 3600 mg daily (1200 mg to 3600 mg gabapentin encarbil) can provide good levels of pain relief to some people with postherpetic neuralgia and peripheral diabetic neuropathy. Evidence for other types of neuropathic pain is very limited. Gabapentin is a drug used to treat nerve pain. This type of pain is often not relieved by normal painkillers. It can be used in combination with other painkillers to improve your pain relief. How does gabapentin work? Gabapentin works by changing the way in which nerves send messages to your brain. Gabapentin (Neurontin) and pregabalin (Lyrica) both belong to a class of drugs called gabapentinoids, which means they work in similar ways. They're both used to treat chronic pain in certain Frequent use of gabapentin for back pain may raise the risk of dementia by 29% and mild cognitive impairment by 85%, new study finds. Abstract Background: This review is an update of a review published in 2011, itself a major update of previous reviews published in 2005 and 2000, investigating the effects of gabapentin in chronic neuropathic pain (pain due to nerve damage). Antiepileptic drugs are used to manage chronic neuropathic pain and fibromyalgia. Management of patients with chronic pain in primary care practice can be difficult. When faced with patients who are struggling with pain, the path of least resistance is often to write a Overview of pharmacologic management of chronic pain in adults, including medication options and treatment strategies. In order to maintain appropriate access for those patients who do obtain substantial pain relief and to minimise misuse and abuse there is a need for a comprehensive understanding of the safety and harms of gabapentinoids. This review considers serious side effects and harms that have been reported with gabapentinoids. Gabapentin at doses of 1800 mg to 3600 mg daily (1200 mg to 3600 mg gabapentin encarbil) can provide good levels of pain relief to some people with postherpetic neuralgia and peripheral diabetic neuropathy. A drug used to treat seizures, nerve pain and restless leg syndrome might be linked with increased risk of dementia, a new study says. Regular gabapentin use appeared to increase risk of dementia by 29% and mild cognitive impairment (MCI) by 85%, researchers reported July 10
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