Abstract Objective: To review the literature examining the use of gabapentin for treatment of hot flashes during natural or surgically induced menopause. An investigational nonhormonal drug, extended-release gabapentin, effectively improved sleep and reduced hot flashes in menopausal women. Abstract Objective: Gabapentin is used to treat vasomotor symptoms (VMS) in postmenopausal women with contraindications to hormonal therapy or who prefer alternatives. We investigated the efficacy and tolerability of gabapentin for treating menopausal hot flushes via a meta-analysis. My doctor recommended gabapentin (100 mg, up to 3 times daily) to help with night sweats and interrupted sleep. Has anyone else used it? Any side effects? I’m afraid of the mood changes and edema that I’ve seen referenced in my side effect searches. Vasomotor symptoms are common among postmenopausal women and patients receiving hormone deprivation therapies, and emerging studies are exploring gabapentin’s and pregabalin’s effects as nonhormonal treatment options. We aimed to assess the efficacy and safety of these 2 drugs. Buy SDC Metrics Abstract Objective: Gabapentin is used to treat vasomotor symptoms (VMS) in postmenopausal women with contraindications to hormonal therapy or who prefer alternatives. We investigated the efficacy and tolerability of gabapentin for treating menopausal hot flushes via a meta-analysis. Methods: Abstract Objective: To compare the effectiveness and tolerability of gabapentin with placebo for the treatment of hot flashes in women who enter menopause naturally. Several studies have shown that gabapentin (Neurontin) at 600-2400 mg/day in divided doses is effective for treating hot flashes in menopausal women. Research presented at the annual meeting of the North American Menopause Society (NAMS) indicates that an investigational extended release (ER) formulation of gabapentin (Serada, Depomed) is effective for the treatment of hot flashes and sleep HRT is the current go-to treatment for menopausal hot flashes. Gabapentin offers non-hormonal relief and reduction in hot flashes and night sweats. Various non-hormonal agents have been used for the treatment of hot flashes in women with menopause. Some studies have reported that gabapentin appears to be an effective and well-tolerated treatment modality. The aim of this study was to evaluate Reviews and ratings for Gabapentin when used in the treatment of hot flashes. 123 reviews submitted with a 8.5 average score. The North American Menopause society and the American College of Obstetricians and Gynecologists recommend gabapentin as an option for managing hot flashes in women who are unwilling to take estrogen-containing supplements. This article reviews the evidence for the use of non-hormonal pharmacologic therapies for the treatment of menopausal symptoms including antidepressants, gabapentinoids, clonidine and anticholinergics. We also review data on emerging therapies including the latest evidence on neurokinin-1 and -3 antagonists. Gabapentin is an effective medication for managing menopausal hot flashes, offering relief by targeting neurological pathways and reducing the intensity of symptoms. In this review, we address common issues related to menopause HFs and suggest a stepwise approach to their management. KEYWORDS: Hormone replacement therapy, hot flashes, menopause I NTRODUCTION M ore than 80% of women experience hot flashes (HFs) during menopause. Objective: To investigate the efficacy and tolerability of gabapentin for the treatment of menopausal hot flashes, we performed a systematic review of all trials reporting on the efficacy and tolerability of gabapentin in women with hot flashes and a meta-analysis of the randomized controlled trials (RCTs) conducted in this patient population. This review investigated the efficacy and tolerability of gabapentin for the treatment of hot flashes in menopausal women. Gabapentin was associated with reductions in the severity and frequency of hot flashes in menopausal women, but there was substantial variation in the results across the included trials. The authors' conclusions appear to be reliable based on the evidence presented. Gabapentin is currently used for a variety of conditions/symptoms, such as epilepsy, pain after shingles (post herpetic neuralgia), insomnia, chronic pain restless leg syndrome, and anxiety. And of course, hot flashes. The Menopause Society, formerly known as the North American Menopause Society, recommends certain evidence-based lifestyle interventions, mind-body therapies, and procedures for managing VMS. Randomized controlled trials have demonstrated that weight loss may be effective for reducing VMS, particularly earlier in the menopause transition.
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