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Gabapentin was found to be effective in a double-blind, placebo-controlled trial for migraine prophylaxis in patients with or without aura (56 patients) over placebo (31 patients) at a stable dose of 2400 mg/day, obtaining a significant reduction in 4-week migraine rate (2.7 for gabapentin- and 3.5 for placebo-treated patients respectively Migraine Prophylaxis in Children Propranolol is commonly prescribed for migraine preventive treatment in children, although studies have shown conflicting results. Gabapentin enacarbil is not efficacious for the prophylaxis of episodic migraine in adults. There is no published evidence from controlled trials of pregabalin for the prophylaxis of episodic migraine in adults. Gabapentin does not decrease the frequency of migraine headaches and is not recommended for prophylactic therapy. Studies were required to be prospective, controlled trials of gabapentin/gabapentin enacarbil or pregabalin taken regularly to prevent the occurrence of migraine attacks, to improve migraine-related quality of life, or both. Two review authors independently selected studies and extracted data. Gabapentin Gabapentin’s mode of action in migraine is unclear (66). It interacts with the α2δ-subunit of the calcium channel and increases the concentration and probably the syn-thesis of brain γ -aminobutyric acid (GABA). Calcitonin gene-related peptide inhibitors. Do NOT offer gabapentin for migraine prophylaxis. Consider non-pharmacological therapies as an adjunct or alternative to pharmacological therapy depending on the specific clinical situation and the person’s preference, including: Our observations indicate that gabapentin is well tolerated by patients and that reduces headache frequency and use of symptomatic drugs in both groups. Gabapentin shows to have an effective therapeutic action in the prophylactic treatment of migraine. Types of interventions Included studies were required to have at least one arm in which gabapentin or pregabalin (without concomitant use of other migraine prophylactic treatment) was given regularly during headache‐free intervals with the aim of preventing the occurrence of migraine attacks, improving migraine‐related quality of life, or both. Gabapentin is a drug that’s approved to help prevent seizures in people with epilepsy and treat nerve pain from shingles. It’s also sometimes used off-label for migraine prevention. Migraine headaches are a debilitating condition that affects approximately 1% of the US population. Goals of migraine prophylaxis include reduction in headache severity and frequency, improved Objective.—To compare gabapentin with placebo for use as a prophylactic agent in patients with migraine (with or without aura). Study Design and Treatment.—After screening, a 4-week, single-blind, pl Discover the potential of gabapentin for preventing migraine attacks and headaches. While not a first-line treatment, it can be effective in combination with other options. Abstract Migraine is often a chronic and disabling disorder. The objective of our study was to assess the efficacy and safety of gabapentin in the prophylaxis of migraine in patients refractory to other prophylactic treatments. The study included 67 migraine patients, 55 women and 12 men; 52 patients completed this prospective, open-label study. Gabapentin is used "off-label" for migraine prevention and treatment, including migraines with or without aura, vestibular migraines. It reduces the frequency of headaches, pain intensity, and the use of symptomatic medications 1, 2. While there are several trials that support the efficacy of various drugs for migraine prophylaxis against placebo, there is limited evidence addressing the comparative safety and efficacy of these drugs. We conducted a systematic review and network meta-analysis to facilitate comparison between drugs for migraine prophylaxis. Objective: Gabapentin is an antiepileptic drug of new generation that increases brain GABA levels. We report the results of a three-month randomised double-blind placebo-controlled study on the effects of gabapentin in the prophylaxis of patients with migraine meeting the IHS criteria. Patients and Methods. We treated 63 patients suffering from migraine with or without aura. Patients treated Gabapentin is an effective prophylactic agent for patients with migraine. In addition, gabapentin appears generally well tolerated with mild to moderate somnolence and dizziness. The migraine headache rate during the second 4 weeks of the SP2 for patients maintaining a stable dose of 2400 mg/day gabapentin is presented in Table 3 for the placebo- and gabapentin-treatment groups. Report on gabapentin (Neurontin®) for migraine prophylaxis: evaluation of efficacy, effectiveness and marketing Expert consultant’s report Prepared by Douglas C. McCrory, MD, MHS
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