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Firm evidence for use of gabapentin is lacking as clinically relevant beneficial effect of gabapentin may be absent and harm is imminent, especially when added to multi-modal analgesia. Editorial Comment In this trustworthy systematic review, use of gabapentin for post-operative pain management was scrutinized. The shift towards multimodal pain regimens, including gabapentin, has taken place without attention to ensuring that they, like opioids, are appropriately discontinued soon after surgery. The prevalence of prolonged use of post-operative gabapentin among older adults is unknown, as are the factors associated with prolonged use. Gabapentin is a novel drug used for the treatment of postoperative pain with antihyperalgesic properties and a unique mechanism of action, which differentiates it from other commonly used drugs. Various studies have shown that perioperative use of gabapentin reduces postoperative pain. SUMMARY Gabapentin (NeurontinTM) has gained significant interest as part of a multi-modal pain management strategy for the control of acute pain. There has been considerable variation in both the dose and the regimen used in recent clinical trials. Most have relied on pre-operative dosing and have utilized a single dose of 300 to 1200 mg. Higher doses seem to show a decrease in postoperative Abstract Background: Perioperative pain treatment often consist of combinations of non-opioid and opioid analgesics, 'multimodal analgesia', in which gabapentin is currently used. The aim was to document beneficial and harmful effects of perioperative gabapentin treatment. Conclusion Gabapentin, pregabalin, and duloxetine have potential to further decrease post-operative pain and lower opioid dependency. This review creates an opening for further research in hand surgery to assess an updated protocol for pain management to reduce opioid dependency. These results were consistent regardless of the type of drug (gabapentin or pregabalin). No effect was observed on pain intensity at 72 h, subacute and chronic pain. The use of gabapentinoids was associated with a lower risk of postoperative nausea and vomiting but with more dizziness and visual disturbance. Gabapentin, an anticonvulsant, has recently been suggested as an effective postoperative ‘analgesic’ agent. The objective of the present study was to examine the analgesic effectiveness, opioid-sparing effects and side effects associated with the This review evaluated the efficacy and tolerability of peri-operative gabapentin administration to control acute post-operative pain. Peri-operative gabapentin administration was found to be effective in reducing pain scores, opioid requirements and opioid-related adverse effects in the first 24 hours after surgery. Given the significant differences between the studies and the possibility of We would like to show you a description here but the site won’t allow us. Background Gabapentin is an antiepileptic drug used in a variety of chronic pain conditions. Increasing numbers of randomized trials indicate that gabapentin is effective as a postoperative analgesic. This procedure-specific systematic review aims to analyse the 24-hour postoperative effect of gabapentin on acute pain in adults. Methods Medline, The Cochrane Library and Google Scholar were Key takeaways Some doctors will prescribe gabapentin either before or after surgery to help manage postsurgical pain and reduce the need for opioid painkillers. Gabapentin may cause side effects, and it can also cause abuse or dependence. It may also cause withdrawal, especially in patients who stop treatment abruptly. Opioids are another common treatment for postoperative pain, but they also The search was conducted using the following keywords: Gabapentin, gabapentinoids, enhanced recovery after surgery, ERAS, enhanced recovery, postoperative pain, abdominal operations, gastrointestinal surgery, abdominal gynecologic surgery, abdominal procedures, laparotomy, and postoperative pain. The following keywords including pain management, postoperative pain, total knee arthroplasties, total knee replacement, and gabapentin were used for searching. 1. Inclusion criteria. Studies were considered eligible for inclusion if they met the following criteria: Study design: Randomized controlled trials (RCTs) with placebo report in English. This randomized clinical trial evaluates the effects of perioperative administration of gabapentin on postoperative pain resolution and time to cessation of opioid use. This systematic review demonstrated that preoperative gabapentin administration was useful for postoperative pain management. A single preoperative dose of gabapentin, 1200 mg or less, effectively reduced pain intensity and opioid consumption for the first 24 h after surgery. In the subgroup that received a single 1200 mg of gabapentin preoperatively, the time to first request for rescue Abstract Purpose of review: This review summarizes the risks and benefits of gabapentinoids (gabapentin and pregabalin) for perioperative pain control and the controversies surrounding their use in a variety of settings. We review current literature with the goal of providing patient-centric and procedure-specific recommendations for the use of these medications. Conclusion: The preoperative administration of gabapentin appears to be an effective strategy for enhancing postoperative pain control and reducing opioid use in orthopedic patients undergoing spinal anesthesia. Further studies are necessary to determine the optimal dosing regimen and long-term effects of gabapentin in this setting. Gabapentin is an antiepileptic drug used in a variety of chronic pain conditions. Increasing numbers of randomized trials indicate that gabapentin is effective as a postoperative analgesic. This procedure-specific systematic review aims to analyse Gabapentin, an anticonvulsant, has recently been suggested as an effective postoperative ‘analgesic’ agent. The objective of the present study was to examine the analgesic effectiveness, opioid-sparing effects and side effects associated with the
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