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Gabapentin is a γ-aminobutyric acid analog formally indicated for the treatment of epilepsy and neuropathic pain that is gaining increased popularity. Gabapentin has been historically considered a safe medication, including during pregnancy and lactation, with low reported concerns for misuse and us Gabapentin is an anti-seizure drug and some of these can affect folic acid levels. Women taking gabapentin while trying to conceive and during pregnancy should therefore be prescribed a high dose folic acid supplement (5mg/day). Methods A systematic review was performed in PubMed and Reprotox using the search terms: “gabapentin”, “pregabalin”, “antiepileptic drugs” and terms associated with pregnancy. We included all studies in English that reported on the use and safety of gabapentin and pregabalin during pregnancy. ( gab ah pen' tin) Neurontin Pregnancy Category C Drug class Antiepileptic Therapeutic actions Gabapentin is a pregnancy category C, which means risk cannot be ruled out. Does gabapentin cause birth defects? There is currently not enough data to determine the risk of major birth defects in humans. Gabapentin is a pregnancy category C, which means risk cannot be ruled out. Lactation Gabapentin can be transmitted through human milk. Gabapentin, sold under the brand name Neurontin among others, is an anticonvulsant medication primarily used to treat neuropathic pain and also for partial seizures [10][7] of epilepsy. It is a commonly used medication for the treatment of neuropathic pain caused by diabetic neuropathy, postherpetic neuralgia, and central pain. [11] It is moderately effective: about 30–40% of those given Gabapentin package insert / prescribing information for healthcare professionals. Includes: indications, dosage, adverse reactions and pharmacology. Gabapentin is a Pregnancy Category C drug and Animal studies suggest that it can harm an unborn child and therefore should be avoided during pregnancy. In a cohort study of pregnant women included in the US Medicaid Analytic eXtract (MAX) dataset, Elisabetta Patorno and colleagues investigate neonatal and maternal outcomes associated with gabapentin exposure during pregnancy. Author summary Why was this study done? In addition to being currently US Food and Drug Administration (FDA)-approved for the treatment of partial seizures and Gabapentin is an anti-epileptic drug, also called an anticonvulsant. It is used to treat some types of seizures and nerve pain caused by shingles. View gabapentin information, including dose, uses, side-effects, renal impairment, pregnancy, breast feeding, monitoring requirements and important safety information. Gabarone package insert / prescribing information for healthcare professionals. Includes: indications, dosage, adverse reactions and pharmacology. This sheet is about exposure to gabapentin in pregnancy and while breastfeeding. This information is based on available published literature. It should not take the place of medical care and advice from your healthcare provider. Overview of the five pregnancy risk categories, established by the FDA to indicate the potential of a drug to cause birth defects if used during pregnancy. Gabapentin (Neurontin) is an antiepileptic drug that is now used to treat a wide variety of clinical settings — for the treatment of pain management, restless leg syndrome, anxiety, and sleep disturbance. So far, data regarding the use of gabapentin during pregnancy has been reassuring, and it does not appear that gabapentin Data from the Medicaid Analytic eXtract The largest study to date Advice and warnings for the use of Gabapentin during pregnancy. FDA Pregnancy Category C - Risk cannot be ruled out If you're trying to get pregnant or have become pregnant while taking gabapentin, it is recommended to take a high dose of folic acid (5mg a day). You can get this from your doctor or midwife. Ideally you'll take high dose folic acid for 3 months before you start trying to get pregnant and for the first 12 weeks of pregnancy. There is a pregnancy exposure registry that monitors pregnancy outcomes in women exposed to antiepileptic drugs (AEDs), such as NEURONTIN, during pregnancy. Encourage women who are taking NEURONTIN during pregnancy to enroll in the North American Antiepileptic Drug (NAAED) Pregnancy Registry by calling the toll free number 1-888-233-2334 or Abstract Background: Despite the widespread use, only sparse information is available on the safety of gabapentin during pregnancy. We sought to evaluate the association between gabapentin exposure during pregnancy and risk of adverse neonatal and maternal outcomes.
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