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Description Gabapentin enacarbil is used to treat moderate-to-severe primary Restless Legs Syndrome (RLS). RLS is a neurologic disorder that makes the legs feel uncomfortable. This results in an irresistible feeling of wanting to move your legs to make them comfortable. Gabapentin enacarbil is also used to manage a condition called postherpetic neuralgia, which is pain that occurs after Restless legs syndrome: Gabapentin Last revised in June 2025 The use of gabapentin for restless legs syndrome (RLS) is off-label. Initial dose of 300 mg if the person is under 65 years old and 100 mg if the person is over 65 years old. Abstract Objective: To assess the effects of gabapentin on sensory and motor symptoms in patients with restless legs syndrome (RLS). Methods: Patients with RLS (22 idiopathic, 2 secondary to iron deficiency) were randomized and treated for 6 weeks with either gabapentin or placebo. Restless legs syndrome (RLS)/Willis-Ekbom disease is a neurologic disorder characterized by a strong desire to move when at rest (usually in the evening) and paraesthesia in their lower legs. The most widely used therapies for first-line treatment Restless legs syndrome (RLS) is a common sleep-related neurological disorder that is characterized by the urge to move, worsening at rest, improvement with activity, and worsening in the evening and night. Dopamine agonists are usually the Restless legs syndrome is a common neurologic movement disorder that affects approximately 10 percent of adults. Of those affected with this condition, approximately one third have symptoms severe A randomized, double-blind, placebo-controlled study to assess the efficacy and tolerability of gabapentin enacarbil in subjects with restless legs syndrome. J Clin Sleep Med 2011;7:282–292. A. Gabapentin enacarbil (Horizant) has been approved by the FDA for the treatment of restless legs syndrome (RLS) and postherpetic neuralgia (the pain that can linger after a bout of shingles). Restless legs syndrome (RLS) is a common disorder. The population prevalence is 1.5% to 2.7% in a subgroup of patients having more severe RLS with symptoms occurring 2 or more times a week and causing at least moderate distress. It is important for primary care physicians to be familiar with the disorder and its management. Much has changed in the management of RLS since our previous revised Restless legs syndrome (RLS) is a common disorder. The population prevalence is 1.5% to 2.7% in a subgroup of patients having more severe RLS with symptoms occurring 2 or more times a week and causing at least moderate distress. It is important for primary care physicians to be familiar with the disorder and its management. Much has changed in the management of RLS since our previous revised Treatment of Restless Legs Syndrome in Adults This information sheet is provided to help you understand the evidence for treating restless legs syndrome (RLS). It is a service of the American Academy of Neurology (AAN). Gabapentin, or Neurontin, is a medication primarily used to treat conditions such as epilepsy, neuropathic pain, and anxiety disorders. However, its effectiveness in managing RLS symptoms has made it an increasingly popular treatment option. Key takeaways Although gabapentin is traditionally prescribed for seizure management and postherpetic neuralgia, it is also used off-label for restless legs syndrome (RLS) and many other nerve conditions. Gabapentin enacarbil is one of four medications approved by the U.S. Food and Drug Administration (FDA) for the treatment of RLS. Gabapentin helps improve the nerve signals to the muscles of Restless Legs Syndrome (RLS), also known as Willis-Ekborn disease, is a common sensory motor neurological disorder which causes a characteristic, overwhelming and irresistible urge to move the limbs, usually the legs but can also additionally affect the arms – in addition to uncomfortable, abnormal sensations which appear without any sensory Gabapentin can help alleviate the uncomfortable sensations and urge to move the legs that are characteristic of RLS. How Gabapentin Works for RLS Gabapentin is an anticonvulsant and neuropathic pain medication. It’s thought to work by modulating neurotransmitters in the brain, especially those related to pain signaling and nerve activity. A new clinical practice guideline developed by the AASM provides updated recommendations for the treatment of restless legs syndrome. Use of the international restless legs syndrome severity scale remains a requirement for FDA approval. This guideline, with the accompanying systematic review, 20 provides a comprehensive update of the available evidence and a synthesis of clinical practice recommendations for the treatment of RLS and PLMD in adults and children. The FDA approved gabapentin enacarbil in 2011 as the first non-dopaminergic agent for the treatment of restless legs syndrome (RLS) symptoms. Although gabapentin enacarbil is a pro-drug of gabapentin, its pharmacokinetics differ. Absorption of Summary Restless legs syndrome (RLS) is characterized by an uncomfortable urge to move the legs while at rest, relief upon movement or getting up to walk, and worsened symptom severity at night. RLS may be primary (idiopathic) or secondary to pregnancy or a variety of systemic disorders, especially iron deficiency, and chronic renal insufficiency. Learn about gabapentin, sold under the brand name Neurontin or Horizant, which can treat the uncomfortable sensations that occur in restless leg syndrome (RLS).
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