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Gabapentin, an apha-2-delta voltage-gated calcium channel ligand (8) that is widely used for the treatment of epilepsy, neuropathic pain, and restless legs syndrome, can enhance slow-wave sleep in both normal individuals (9) and epileptic patients (10, 11) and can improve slow-wave sleep and sleep efficiency and reduce nighttime awakening in Abstract Sleep deprivation is a prevalent problem in critically ill patients, which leads to delayed recovery and delirium. Slow-wave sleep (SWS) is essential to energy restoration, tissue repair, and immune system strengthening. This study aimed to investigate the effects of gabapentin on SWS in critically ill patients. Gabapentin and sleep Most studies show that gabapentin improves slow wave sleep (“deep sleep”) and total sleep time. Two small studies showed that gabapentin may help people with primary insomnia and occasional sleep disturbance improve total sleep time and wakefulness in the morning. Gabapentin, an apha-2-delta voltage-gated calcium channel ligand (8) that is widely used for the treatment of epilepsy, neuropathic pain, and restless legs syndrome, can enhance slow-wave sleep in both normal individuals (9) and epileptic patients (10, 11) and can improve slow-wave sleep and sleep efficiency and reduce nighttime awakening in Abstract Summary: Purpose: The older antiepileptic drugs (AEDs) have a variety of effects on sleep, including marked reduction in rapid-eye-movement (REM) sleep, slow-wave sleep (SWS), and sleep latency, and an increase in light sleep. The effects of the newer AEDs on sleep are unknown. Our purpose was to study the effect of gabapentin (GBP) on Conclusions: Gabapentin enhances slow-wave sleep in patients with primary insomnia. It also improves sleep quality by elevating sleep ef-ficiency and decreasing spontaneous arousal. The results suggest that gabapentin may be beneficial in the treatment of primary insomnia. In studies using healthy volunteers, gabapentin increased slow wave sleep, 12, 13 and in healthy individuals administered alcohol prior to bedtime (known to disrupt sleep), gabapentin increased slow wave sleep, reduced stage 1 sleep, and decreased number of awakenings. 14 Gabapentin, as add-on or monotherapy, produced similar changes in PSG Increased slow-wave sleep (SWS): Studies have demonstrated that gabapentin can increase the amount of deep, restorative sleep. Reduced sleep fragmentation: Gabapentin has been shown to decrease the number of awakenings during the night, leading to more consolidated sleep. Abstract Purpose: The older antiepileptic drugs (AEDs) have a variety of effects on sleep, including marked reduction in rapid-eye-movement (REM) sleep, slow-wave sleep (SWS), and sleep latency, and an increase in light sleep. The effects of the newer AEDs on sleep are unknown. Our purpose was to study the effect of gabapentin (GBP) on sleep. Research has shown that gabapentin can modify sleep stages, typically enhancing slow-wave sleep and REM sleep duration. These stages are essential for restorative processes, memory consolidation, and overall health. However, the impact varies and is still under study. Study Objectives:To evaluate the effects of single doses of gabapentin 250 and 500 mg on polysomnographic (PSG) and participant-reported sleep measures in a 5-h phase advance insomnia model.Methods:Adults reporting occasional disturbed sleep received It appears as though gabapentin: increases slow-wave sleep, decreases fast-wave sleep, favorably modulates transitioning between sleep cycles, reduces spontaneous arousal index, and increases heart-rate variability. Slow wave sleep (SWS) was visually identified as synchronized slow wave activity (1–4 Hz) during the 5-h EEG recording sessions that included baseline, saline injection control, gapabentin 30 mg/kg, and gabapentin 120 mg/kg. Slow‐wave sleep (SWS) is essential to energy restoration, tissue repair, and immune system strengthening. This study aimed to investigate the effects of gabapentin on SWS in critically ill patients. Gabapentin enhances slow-wave sleep in patients with primary insomnia. It also improves sleep quality by elevating sleep efficiency and decreasing spontaneous arousal. The results suggest that gabapentin may be beneficial in the treatment of primary insomnia. Some studies have found that gabapentin may increase slow-wave sleep, also known as deep sleep, which is crucial for physical restoration and cognitive function. Sleep deprivation is a prevalent problem in critically ill patients, which leads to delayed recovery and delirium. Slow-wave sleep (SWS) is essential to energy restoration, tissue repair, and immune system strengthening. This study aimed to investigate the effects of gabapentin on SWS in critically Highlights Gabapentin is an anticonvulsant that is primarily used to treat seizures, but it can be used off-label as a sleep aid. Gabapentin can reduce nighttime awakenings and promote more slow-wave sleep. There is a risk of misuse and dependence on gabapentin, which leads to potential concerns regarding its long-term use. Results: Polysomnographic study revealed increased sleep efficiency and slow-wave sleep, decreased wake after sleep onset, and spontaneous arousal index after gabapentin treatment. The biochemical blood test revealed decreased prolactin levels in the morning after treatment.
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