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4 DOSAGE AND ADMINISTRATION 4.1 Dosing Considerations Because TEVA-GABAPENTIN is eliminated solely by renal excretion, dosage adjustments are recommended for patients with renal impairment (including elderly patients with declining renal function) and patients undergoing hemodialysis. if you prescribe are on haemodialysis a different dosing Gabapentin, the active of Gabapentin products because of kidney (to remove schedule. Capsules, is passed on substance through human doctor if you develop muscle failure), tell your waste Because the effect on the baby is unknown, it is weakness. pain and/or Gabapentin recommended Capsules. to breast-feed while using if you develop Gabapentin (standard dose increase) Patient Information The information in this leaflet is to guide your use of gabapentin safely. Further information is available inside the medication packaging. Some medicines used to treat pain symptoms are used for other health reasons. For example some medicines used to treat epilepsy can help to improve nerve pain. Your doctor, nurse or pharmacist will Gabapentin is used to relieve pain from the nerves, from the spinal cord, or from the brain. Nerve pain may be associated with shingles (herpes zoster), diabetic neuropathy, peripheral neuropathy, sciatica, trigeminal neuralgia and other conditions. Gabapentin is also used in the management of certain types of seizures in adults and children with epilepsy. How do I take this medicine? Monitor for drowsiness, mood changes, suicidal/homicidal thoughts, weight gain, urinary dysfunction, bowel changes, and confusion. ave side effects. Stay at this dose unt Continue the titration schedule to the goal of 1800 mg/day of GABAPENTIN. ceptable for you. Not all patients will require the full schedul Initiate dose at 10mg/night and gradually up-titrate as tolerated at 2-4 • Counsel patient that it can take up to 12 weeks to achieve a therapeutic week intervals up to 25mg/night to allow acclimatisation of potential side- response. Daily Dose of Lyrica (mg/day) 50 75 100 150 200 250 300 350 400 450 500 600 ted therapeutic dose is important. The therapeutic dosing range in neuropathic pain trials is 1800-3 00 mg/day (normal renal function). The pharmacokinetics of gabapentin require egular dosing, it will dosed “as needed.” To minimize side effects, your doctor will prescribe gabapentin at a low dose and increase the dose slowly. Examples of gabapentin dosing schedules are below. Example A (using gabapentin 100mg capsules) Example B (using gabapentin 300mg capsules) Week 1: 1 capsule at bedtime Week 2: 1 capsule in the morning and 1 capsule at bedtime The dose of gabapentin tablets should be adjusted in patients with reduced renal function, according to Table 2. Patients with reduced renal function must initiate gabapentin tablets at a daily dose of 300 mg. Gabapentin tablets should be titrated following the schedule outlined in Table 1. Daily dosing in patients with reduced renal function must be individualized based on tolerability and The dose can be increased further if necessary. Slow titration table for elderly patients or patients who are sensitive to Gabapentin Stay on this dose for a few days and if pain relief is adequate remain at this, but if pain is still a problem, try increasing the tablets as follows (see overleaf). Advise patient on the medication, titration regime (see drug specific information below) and target dose. Document target dose on traffic light assessment tool sheet /PIL The recommended maintenance dose of NEURONTIN in patients 5 to 11 years of age is 25 mg/kg/day to 35 mg/kg/day, given in three divided doses. NEURONTIN may be administered as the oral solution, capsule, or tablet, or using combinations of these formulations. Dosages up to 50 mg/kg/day have been well tolerated in a long-term clinical study. Gabapentin is a drug used to treat epilepsy and neuropathic pain. It also has some effect on spasticity and can be used in combination with other drugs as an off-label use; it is particularly useful if pain and spasticity co-exist. The maximum dose is 3600 mg per day in divided doses. PROVIDE CLEAR DOSING AND TITRATION GUIDELINES Gabapentin has a short half-life and has to be dosed three to four times daily. To reduce troublesome adverse effects that can occur upon initiation (eg somnolence, dizziness, and ataxia), start with an evening dose,1 and then gradually up-titrate the dose as tolerated. It may take up to 4 weeks to achieve the optimal dose. DESCRIPTION Neurontin® (gabapentin) Capsules, Neurontin (gabapentin) Tablets, and Neurontin (gabapentin) Oral Solution are supplied as imprinted hard shell capsules containing 100 mg, 300 mg, and 400 mg of gabapentin, elliptical film-coated tablets containing 600 mg and 800 mg of gabapentin or an oral solution containing 250 mg/5 mL of gabapentin. 26. Patients should be made aware of the importance of dosage titration, the titration process and the requirement to take a stable regime for a few weeks (up to 8 weeks for gabapentin with at least 2 weeks at maximum dose, and 4 weeks for pregabalin) before assessing for improvement in pain.5 27. The recommended maintenance dose of NEURONTIN in patients 5 to 11 years of age is 25 mg/kg/day to 35 mg/kg/day, given in three divided doses. NEURONTIN may be administered as the oral solution, capsule, or tablet, or using combinations of these formulations. Dosages up to 50 mg/kg/day have been well tolerated in a long-term clinical study. NEURONATIN (GABAPENTIN) TITRATION INSTRUCTIONS Day 1 and Day 2: Take one pill at night MEDICATION TITRATION SCHEDULE FOR GABAPENTIN & PREGABALIN Gabapentin 100MG (Amount of pills to take) Gabapentin 300MG (Amount of pills to take) For any questions please contact our office. Gabapentin Titration Schedule - Free download as PDF File (.pdf), Text File (.txt) or read online for free.
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