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The common signs and symptoms of gabapentin withdrawal syndrome include development of hypertension, tachycardia, agitation, delirium, confusion, anxiety, combativeness, hallucinations, disorientation, paranoid delusions, tremor and increased muscle tone. 11–14 Critical withdrawal symptoms including status epilepticus and catatonia have also Gabapentin Withdrawal Presenting as Catatonia and Altered Mental Status L.F. Henry 1 , A. Khan 4 , P.N. Krupka 2 Common symptoms of gabapentin withdrawal: agitation, confusion, diaphoresis, gastrointestinal upset, headache, and tachycardia (1), more severe complications of akathisia, catatonia, and seizures have been reported (2) Catatonia after benzodiazepine withdrawal. P. Rosebush, M. Mazurek Psychology, Medicine Journal of clinical psychopharmacology 1996 TLDR These cases illustrate that severe and potentially life-threatening catatonia can develop in the wake of benzodiazepine withdrawal and older individuals may be particularly vulnerable to this side effect Gabapentin withdrawal has been reported infrequently, suggesting there may be predisposing conditions for a withdrawal syndrome. AB and an older adult in a previous case report experienced withdrawal despite gabapentin taper. Gabapentin withdrawal can be very unpleasant and uncomfortable, which is why professional detox can help you quit gabapentin and ease your symptoms. The British Association for Psychopharmacology developed an evidence-based consensus guideline on the management of catatonia. A group of international experts from a wide range of disciplines was assembled. Evidence was gathered from existing systematic reviews and the primary literature. Recommendations were made on the basis of this evidence and were graded in terms of their strength. The Catatonia Following Gabapentin Withdrawal Rosebush, Patricia I. MScN, MD, FRCP (C); MacQueen, Glenda M. PhD, MD, FRCP (C); Mazurek, Michael F. MD, FRCP (C) Author A withdrawal syndrome associated with gabapentin may resemble benzodiazepine and ethanol withdrawal. Further the medication chart also showed that she had received gabapentin 1500mg once a day on the third and the fourth post-operative days. A diagnosis of catatonia related to gabapentin withdrawal was made. The woman received treatment with lorazepam. Conclusion Our case illustrates that malignant catatonia can occur in simultaneous benzodiazepine and opioid withdrawal. In this case, initiating scheduled benzodiazepines and fentanyl led to complete resolution of catatonic symptoms, suggesting malignant catatonia in this setting may be particularly amenable to medical therapy. We would like to show you a description here but the site won’t allow us. The cases described eight different types of medications causing withdrawal catatonia, including withdrawal catatonia related to benzodiazepines (24 cases), clozapine (20 cases), combined alcohol and benzodiazepines (4 cases), alcohol (2 cases), glutethimide (2 cases), zolpidem (1 case), gabapentin (1 case), and gamma-hydroxybutyric acid (1 case). Request PDF | On May 1, 2020, L.F. Henry and others published Gabapentin Withdrawal Presenting as Catatonia and Altered Mental Status | Find, read and cite all the research you need on ResearchGate Starting from 2025 Volume 26, Issue 1, Alpha Psychiatry will be published by IMR Press. Request PDF | On Nov 1, 2017, Jay S. Kothari published Gabapentin as a Treatment for unremitting catatonia: Case reports | Find, read and cite all the research you need on ResearchGate Catatonia following gabapentin withdrawalJ Clin Psychopharmacol. 1999 Apr;19 (2):188-9. doi: 10.1097/00004714-199904000-00019. The clinical presentations of benzodiazepine withdrawal catatonia and clozapine withdrawal catatonia appear to differ and reasons for this are explored. The British Association for Psychopharmacology developed an evidence-based consensus guideline on the management of catatonia. A group of international experts from a wide range of disciplines was assembled. Evidence was gathered from existing Although trials have examined the use of gabapentin for ethanol withdrawal, [10–15] we are unaware of studies that used gabapentin for benzodiazepine-resistant ethanol withdrawal symptoms.
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