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Abstract We investigated, in a randomized, placebo-controlled, double-blind study, the efficacy and safety of gabapentin on pain after abdominal hysterectomy and on tramadol consumption in patients. The 50 patients were randomized to receive either oral placebo or gabapentin 1200 mg 1 h before surgery. Pain scores after abdominal hysterectomy were reduced more with gabapentin alone (preoperative dosing) than when gabapentin was given both preoperatively and postoperatively. The benefits of gabapentin for minimally invasive hysterectomy (MIH) are not as well defined. Would you want to take Lyrica (pregabalin) or Neurontin (gabapentin) for pain relief after a major surgery? Both drugs belong to a class of nerve medication called gabapentinoids that are increasingly being prescribed to patients perioperatively (after surgery) as an alternative to opioid medication. It is a novel drug used for the treatment of postoperative pain with antihyperalgesic properties and a unique mechanism of action. Gabapentin and the related, more potent compound pregabalin have been shown to be beneficial in the treatment of neuropathic pain as well as postoperative pain following spinal surgery and hysterectomy. To evaluate whether a single dose of gabapentin given preoperatively reduces narcotic use 24 hours after minimally invasive hysterectomy (MIH). Doc started me on Neurontin 300 mg once a day (night dose) for first week, then take 300 mg twice a day (morning and night) for next 7 days, then three doses, 300 mg three times a day after that for nerve pain. Question is: what will this medicine do to me? If you take, or have taken Neurontin for nerve pain, how did it make you feel? Extract Summary Background and objective: Gabapentin has been suggested to decrease acute postoperative pain. We evaluated the effect of gabapentin on pain after abdominal hysterectomy. Methods: Sixty patients scheduled for abdominal hysterectomy were randomized to receive orally gabapentin 400 mg 6 hourly or placebo. This randomized clinical trial evaluates the effects of perioperative administration of gabapentin on postoperative pain resolution and time to cessation of opioid use. Optimal dosing of preoperative gabapentin for prevention of postoperative nausea and vomiting after abdominal laparoscopic surgery: A randomized prospective comparative study Abstract BACKGROUND: Gabapentin, an anticonvulsant, has recently been suggested as an effective postoperative ‘analgesic’ agent. The objective of the present study was to examine the analgesic effectiveness, opioid-sparing effects and side effects associated with the use of gabapentin in a perioperative setting. METHODS: Following the Quality of Reporting of Meta-analyses recommendations Methods: A randomized, double-blind, placebo-controlled study was conducted in 90 women undergoing abdominal hysterectomy who were anaesthetized in a standardized fashion. Patients received 300 mg pregabalin, 900 mg gabapentin or placebo, 1–2 hours prior to surgery. Postoperative analgesia was administered at visual analogue scale (VAS) ≥3. The primary outcome was analgesic consumption Pre-emptive use of gabapentin 600 mg orally, significantly decreases postoperative pain and PONV, and also rescues analgesic and anti emetic drug requirements in patients who undergo abdominal hysterectomy. For example, a gabapentin dose of 1.2 grams per day 1 hour before surgery and for 2 days after CABG surgery showed that postoperative pain scores at 1, 2, and 3 days as well as the consumption of tramadol given as a rescue analgesic were significantly lower in the gabapentin group when compared to the placebo group [41]. Gabapentin may be prescribed either before or after surgery to help with postsurgical pain. However, it should be used with caution due to the high risk of abuse. This study revealed that prescribing gabapentin or tramadol, as premedication, was effective in reducing postoperative pain, without any concerning side-effects. Keywords: Gabapentin, Pain Postoperative, Tramadol, Hysterectomy, Analgesia, Preanesthetic Medication 1. Background One of the main concerns that patients deal with surgery is pain after. Outcomes and Data Analyses The primary outcome is prolonged use of gabapentin in the postoperative period, defined as a prescription refilled at 90-180 days after discharge from surgery, a time period based on definitions of prolonged use of opioids after surgical procedures. 20, 25, 26 We calculated the days’ supply and average daily dose. What to Expect Immediately After a Hysterectomy Surgery After your hysterectomy surgery, you’ll be moved to the hospital’s recovery room where nurses will check on you as you recover. We investigated, in a randomized, placebo-controlled, double-blind study, the efficacy and safety of gabapentin on pain after abdominal hysterectomy and on tramadol consumption in patients. The 50 patients were randomized to receive either oral placebo or gabapentin 1200 mg 1 h before surgery. Regimens designed to minimize postoperative opioid use also may include the use of scheduled acetaminophen, gabapentin, and nonsteroidal antiinflammatory drugs. For vaginal hysterectomy, paracervical nerve blocks or intrathecal morphine may be useful. The present study assessed the effects of 1200 mg gabapentin, an anticonvulsant drug that acts through voltage-dependent calcium channels, for the control of postoperative pain in patients undergoing abdominal hysterectomy.
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