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Nonopioid medications provide effective options for managing acute pain in adults, offering alternatives to opioids. Gabapentin is a medication used to treat nerve pain, seizures, and other conditions. Learn about its uses, side effects, and precautions. Gabapentin is an anticonvulsive medication that received approval from the US Food and Drug Administration (FDA) in 1993 and has been available in generic form in the USA since 2004. Gabapentin was originally used as a muscle relaxant and an anti-spasmodic. However, it was later discovered that gabapentin has the potential of an anticonvulsive medication and can be used as an adjunct to more Overview of pharmacologic management of chronic pain in adults, including medication options and treatment strategies. INTRODUCTION Chronic pain is one of the most common reasons that patients seek medical attention. Chronic pain results from combined biologic, psychologic, and social factors, and most often requires a multifactorial approach to management. In addition to nonpharmacologic therapies, many patients require medications to manage pain. This topic will discuss an approach to pharmacologic Abstract Background: Gabapentin is an anticonvulsant that is being used for an increasing number of off-label indications. The purpose of this study is to document the clinical manifestations and outcomes of gabapentin exposures reported to poison centers. Comprehensive guide on evaluating and managing drug poisoning in adults, including diagnosis, treatment strategies, and prevention tips. These medications can cause lethargy or agitation in overdose, increase risk of death combined with opioids, and manifest a withdrawal syndrome. This topic will discuss the evaluation and management of gabapentinoid poisoning and withdrawal. A summary table to facilitate emergency management is provided (table 1). UpToDate UpToDate Expert opinion: Loperamide, gabapentin, and modafinil are becoming drugs of abuse, and as such, should be on the radar of healthcare providers. Recognizing their unique toxicity profiles is imperative in providing optimal resuscitative care. Keywords: Evidence-based emergency medicine; gabapentin; loperamide; modafinil; toxicology. Gabapentin has been made a Schedule V controlled substance in some states, and a number of states have mandated reporting of gabapentin in their Prescription Drug Monitoring Programs [61]. Gabapentin is a controlled drug in the United Kingdom [62]. INTRODUCTION Gabapentin and pregabalin are commonly prescribed medications for the treatment of seizure disorders, neuropathic pain (eg, postherpetic neuralgia), fibromyalgia, anxiety, post-traumatic stress disorder, and restless leg syndrome. Gabapentinoids are commonly ingested in self-harm attempts and often misused for their sedative and euphoric properties. These medications can cause Gabapentinoid poisoning and withdrawal symptoms, including management strategies and clinical considerations, are discussed in this comprehensive resource. Comprehensive information on antiseizure medications, including mechanisms of action, pharmacology, and adverse effects. Toxicity from gabapentin and pregabalin overdose is commonly encountered. Treatment is supportive, and the use of extracorporeal treatments (ECTRs) is controversial. The EXTRIP workgroup conducted systematic reviews of the literature and summarized findings following published methods. Thirty-three articles (30 patient reports and 3 pharmacokinetic studies) met the inclusion criteria. High The most common symptoms reported after gabapentin ingestion include sedation, dizziness, and ataxia [24]. In massive overdose, acute or chronic kidney impairment, or co-ingestion of other sedative (eg, alcohol, benzodiazepines, or opioids), patients may show signs of more pronounced central nervous system (CNS) depression (eg, lethargy, coma). Get the latest information on Gabapentin overdose, including symptoms, treatment options, and more, from UpToDate, the trusted source for medical professionals. Postmortem toxicology tests detected gabapentin in almost 1 in 10 US overdose deaths between 2019 and 2020. In about half of the cases, a medical examiner or coroner ruled the drug was a cause of the death, according to a report from the CDC’s Division of Overdose Prevention. Comprehensive drug information resource for healthcare professionals. Explore pharmacologic management strategies for alcohol use disorder, including treatment options and outcomes, on this comprehensive resource.
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