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Objective: To investigate the possible side effects of prenatal exposure to the antiepileptic drug gabapentin (GBP) on the liver during the organogenesis phase of the rat embryonic development and MeSH terms Anticonvulsants / therapeutic use Cyclohexanecarboxylic Acids* / adverse effects Drug-Related Side Effects and Adverse Reactions* Gabapentin / adverse effects Hepatitis* Humans gamma-Aminobutyric Acid / adverse effects Gapentin is not metabolized by the liver, and its effects on the liver and kidneys are similar to previous studies. In rare cases, gabapentin can cause DRESS (drug reaction with eosinophilia and systemic symptoms). Background & Aims: Antiepileptic drugs (AEDs) are a common cause of drug induced liver injury (DILI). Over the last few decades, several newer AEDs were approved for marketing in the United States, and they are increasingly prescribed for indications other than seizures. Contemporaneous data related to trends and characteristics of liver injury due to AEDs are sparse. Gabapentin (Neurontin) usually isn’t bad for the liver or kidneys, but in rare instances, it can cause DRESS (drug reaction with eosinophilia and systemic symptoms). Gabapentin enacarbil and gabapentin are associated with a low rate of transient serum enzyme elevations during treatment and with rare cases. Gabapentin use isn’t known to affect enzyme or bilirubin levels, but it may rarely cause an allergic reaction characterized by elevated eosinophil levels. This is a condition called eosinophilia, which may cause liver damage. Question I have a patient with trigeminal neuralgia who was taking 1600 mg of gabapentin and had serious elevations of liver function tests (aspartate transaminase 258 U/L, alanine transaminase Medications like Tylenol and Aleve are hepatotoxic, meaning they could raise liver enzymes and damage your liver over time. See the list of medications to avoid. Gabapentin affects nerves and chemicals in your body that are involved in some types of pain and in seizures. There is insufficient data to estimate incidence for these or establish whether gabapentin is the sole cause of elevated liver function tests, notes Pfizer. There are several liver enzymes, but the ones that show liver damage from medications are aspartate transaminase (AST) and alanine transaminase (ALT). Medications may cause liver enzymes to be elevated without serious liver damage until they reach 3 to 5 times the normal levels. References U.S. Food and Drug Administration (FDA). Gabapentin is generally considered safe for the liver, but rare cases of liver damage have been reported. Gabapentin, a medication primarily used to treat nerve pain and seizures, has gained popularity for its effectiveness and relatively mild side effects. However, concerns about its impact on liver health have surfaced among patients and healthcare providers. Understanding whether gabapentin Discussion: Gabapentin induced liver injury is rare with few reported cases, many of which did not exclude other etiologies. In this case, the key elements of diagnosing DILI were met including gabapentin initiation closely preceding liver injury, other etiologies excluded, and discontinuation of gabapentin leading to improvement. A drug-induced liver injury is one of the most common causes of acute liver failure. While acetaminophen is the most common etiology, other offending medications include amoxicillin-clavulanic acid, amiodarone, isoniazid, and fluoroquinolones to name a few. Gabapentin, a gamma-aminobutyric acid (GAB Gabapentin has infrequently been reported to cause liver injury, but the causality in previous reports is contested. Different reports suggest that gabapentin has a low profile of interaction with other drugs, hepatic enzymes, and plasma proteins. It is recommended for controlling seizures, treating nerve pain after having had shingles, and treating restless legs syndrome. Learn about the potential effects of Gabapentin on your liver and kidneys. Find out if it is safe to use and how to protect your organs while taking this medication. Gabapentin doesn’t hurt the liver or kidneys in most cases. However, taking a safe gabapentin dose is important to prevent potential side effects. Gabapentin is a unique anticonvulsant that is used as adjunctive therapy in management of epilepsy and for neuropathic pain syndromes. Therapy with gabapentin is not associated with serum aminotransferase elevations, but several cases of clinically apparent liver injury from gabapentin have been reported. Conclusions Gabapentin is an uncommon cause of DILI reported to cause a hepatocellular, cholestatic, or mixed picture of liver injury. Given the limitations of prior cases, we feel our report most closely ties gabapentin use to the resultant transaminase elevation. Introduction: Gabapentin is an anti-convulsant that is also used off-label to treat neuropathic pain. It is not metabolized by the liver, and there have been few reports of hepatotoxity associated with it. We present a rare case of gabapentin-induced hepatotoxicity occurring in a young male. Case Description/Methods: A 41-year-old male with an extensive past medical history including type 1
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