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Gabapentin is a nerve pain medication and anticonvulsant that has proven to be effective for people who have hard-to-treat depression or other mood disorders. Abstract Background: Gabapentin, a new anti-epileptic agent, has been anecdotally reported to be effective in the treatment of mania. We systematically assessed the response rate in bipolar patients being treated adjunctively with gabapentin for manic symptoms, depressive symptoms, or rapid cycling not responsive to standard treatments. Two new anticonvulsants, lamotrigine and gabapentin, have been used increasingly for bipolar disorder in the past several years. Despite this array of options, bipolar disorder remains a difficult disorder to treat. Some subtypes, such as those characterized by rapid cycling or mixed episodes, have been especially resistant to lithium treatment. Systematic reviews of gabapentin treatment in psychiatric and/or substance use disorders showed inconclusive evidence for efficacy in BD, but possible efficacy for some anxiety disorders [9, 10]. Gabapentin may be a useful drug for the add-on treatment of bipolar patients with poor response to other mood stabilizers. Gabapentin may improve depressive residual symptoms such as irritability, social withdrawal or anxiety. These results should be confirmed in randomized clinical trials. Gabapentin, also known as Gralise and Neurontin, is an anticonvulsant medication typically used in the treatment of epilepsy, along with various other physical and mental health treatments. Always use this medication exactly as prescribed and consult with your doctor prior to starting any other medications (prescribed or over the counter) while taking gabapentin, as adverse effects can occur. Abstract Objective This article reviews evidence-based psychiatric uses of gabapentin, along with associated risks. Method of Research An extensive literature review was conducted, primarily of articles searchable in PubMed, relating to psychiatric uses, safety, and adverse effects of gabapentin. Results Evidence supports gabapentin as a treatment for alcohol withdrawal and alcohol use Explore gabapentin's role in mental health treatment, including its uses, benefits, and potential risks. Learn about dosage, effectiveness, and side effects. Gabapentin is commonly used off-label in the treatment of psychiatric disorders with success, failure, and controversy. A systematic review of the literature was performed to elucidate the evidence for clinical benefit of gabapentin in psychiatric The use of gabapentin in bipolar disorder (BPD) treatment provides an informative case of off-label uptake and abandonment of a new medication. Gabapentin was patented by Warner-Lambert in 1977 and FDA-approved in December1993 for the adjunctive treatment of epilepsy and in 2002 for postherpetic neuralgia (see Appendix 1 for timeline). The gabapentinoids, gabapentin, and pregabalin, target the α<sub>2</sub>δ subunits of voltage-gated calcium channels. Initially licensed for pain and seizures, they have become widely prescribed drugs. Many of these uses are off-label for psychiatric indications, and there is increasing concern abou Unfortunately, gabapentin does not demonstrate efficacy in randomized trials for bipolar disorder and current treatment guidelines do not emphasize its use. Despite of the lack of evidence, reviews of gabapentin prescribing patterns in the United States show that this medication is still being used with alarming frequency for bipolar disorder. How-ever, it does provide initial pilot data in the same sample regarding the possible effectiveness of gabapentin in bi-polar disorder type I, other parts of the bipolar spectrum (bipolar disorder type II and NOS), and unipolar major depressive disorder. Gabapentin for Bipolar Disorder Side Effects Common Side Effects of Gabapentin Gabapentin is a medication that can be used to treat the symptoms of bipolar disorder, but like all medications, it can cause side effects. Some people may experience mild side effects when taking gabapentin, while others may experience more severe side effects. Mild Side Effects Mild side effects of gabapentin may Flowchart of included and excluded studies. Bipolar disorder (BD) Four DB-RCTs investigating the efficacy of gabapentin in BD were identified. 101 patients were randomised to receive gabapentin, 81 to placebo, 30 to lamotrigine and 19 to carbamazepine. The mean age of all randomised patients was 37.5 years and 64.1% were female. Acute treatment Three studies compared gabapentin with three Gabapentin may be a useful drug for the add-on treatment of bipolar patients with poor response to other mood stabilizers. Gabapentin may improve depressive residual symptoms such as irritability, social withdrawal or anxiety. Experts agree that gabapentin doesn’t work for bipolar disorder. Learn more about gabapentin and bipolar as well as what conditions it’s FDA approved to treat. Abstract Despite its prevalence and disease burden, several chasms still exist with regard to the pharmacotherapy of bipolar disorder (BD). Polypharmacy is commonly encountered as a significant proportion of patients remain symptomatic, and the management of the depressive phase of the illness is a particular challenge. Gabapentin and pregabalin have often been prescribed off-label in spite of In fact, much of the push for using gabapentin for bipolar disorder is based on aggressive marketing tactics from the manufacturer, Pfizer, which eventually led to legal action against them. How does gabapentin work for bipolar? Gabapentin is a prescription drug that belongs to a class of medications called anticonvulsants.
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