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New data suggest an association between gabapentin for chronic back pain and increased risk of cognitive impairment, although experts urge caution in drawing any firm conclusions. Conclusions Gabapentin prescription in adults with chronic low back pain is associated with increased risk of dementia and cognitive impairment, particularly in non-elderly adults. Physicians should monitor cognitive outcomes in patients prescribed gabapentin. Introduction Gabapentin, an anticonvulsant medication, has gained popularity in recent years for treating various conditions in elderly patients, including neuropathic pain, epilepsy, and behavioral symptoms associated with dementia. However, as with any medication, its use in older adults comes with unique considerations. This article delves into the safety profile of gabapentin for elderly Adults prescribed gabapentin for chronic low back pain face significantly higher risks of developing dementia and cognitive impairment, particularly those under 65, according to a large-scale analysis of medical records spanning two decades. The study of over 26,000 patients found that younger adults taking gabapentin had more than double the risk of dementia compared to those not prescribed Objective: Previous studies have shown that gabapentin or pregabalin use is associated with cognitive decline. Herein, we aimed to evaluate the association between gabapentin or pregabalin use and the risk of dementia. Methods: In this The authors describe the use of gabapentin in the treatment of 4 outpatients with dementia-associated agitation. On the basis of clinical case reports and the Overt Agitation Severity Scale, all 4 patients had reduced agitation with gabapentin. Three of 4 patients were successfully titrated to a full dose of 2,400mg/day. These findings suggest a possible role for gabapentin in the behavioral Gabapentin prescriptions for chronic back pain were linked to higher dementia and cognitive impairment risk. Risks were especially high for chronic back pain patients ages 35 to 64. The study We would like to show you a description here but the site won’t allow us. For these reasons, gabapentin has recently been included in treatment regimens for agitation in dementia patients [1], [11]. Data regarding the use of gabapentin in AD has been accumulating since 1997. Only a few case reports have shown the efficacy of pregabalin [4], [11]. As we mentioned above, in most of the reviewed cases gabapentin is reported to be a well-tolerated and effective treatment for dementia-associated agitation. However, several case reports in which gabapentin was used for agitation in dementia with Lewy bodies question its appropriateness for all types of dementia-related agitation [14 – 16]. Receiving six or more prescriptions of the drug gabapentin for low back pain is associated with significantly increased risks of developing dementia and mild cognitive impairment (MCI)—29% and A new study warns that gabapentin can significantly increase the risk of dementia and mild cognitive impairment in people taking it for chronic low back pain. ryanking999 – stock.adobe.com Introduction Gabapentin is widely used to treat chronic pain, but its association with cognitive decline and dementia remains unclear. This study examined whether gabapentin prescription is associated with dementia in adults with chronic low back pain. Methods We conducted a retrospective cohort study using the TriNetX national database of de-identified patient records from 2004 to 2024 Gabapentin prescription in adults with chronic low back pain is associated with increased risk of dementia and cognitive impairment, particularly in non-elderly adults. Physicians should monitor cognitive outcomes in patients prescribed gabapentin. Regular gabapentin use appeared to increase risk of dementia by 29% and mild cognitive impairment (MCI) by 85%, researchers reported July 10 in the journal Regional Anesthesia & Pain Medicine. What’s more, the risk was more than doubled in people normally considered too young to suffer from brain aging, those 18 to 64, results show. Behavioral and Psychiatric Symptoms of Dementia (BPSD) increase patient mortality, healthcare costs and caregiver burnout. While behavioral interventions are the most effective treatment for BPSD, many patients are not able to regulate their agitation using only behavioral interventions, and therefore require pharmacotherapy. Various agents such as risperidone, quetiapine and trazodone have According to a large scale observational study published in the journal "Regional Anesthesia & Pain Medicine", patients who received frequent gabapentin prescriptions were significantly more likely to develop dementia and/or mild cognitive impairment (MCI). Researchers analyzed anonymized medical records from tens of thousands of Americans sourced from TriNetX, a federated health research Frequent use of gabapentin for back pain may raise the risk of dementia by 29% and mild cognitive impairment by 85%, new study finds. If you're worried about developing dementia, you've probably memorized the list of things you should do to minimize your risk—eating a healthy diet, exercising regularly, getting adequate sleep, and keeping your mind and soul engaged. In addition, some of the drugs you may be taking to help you accomplish those things could increase your risk of dementia. In two separate large population Research shows that patients with six or more prescriptions for gabapentin, commonly used to treat lower back pain, were 29% more likely to be diagnosed with dementia and 85% more likely to be diagnosed with mild cognitive impairment within 10 years of their initial pain diagnosis.
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