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Gapentin, a water-soluble amino acid, is eliminated unchanged by the kidneys and there is no appreciable metabolism by the liver. An increase in liver parameters due to GPN caused elevated liver enzyme functions (GOT, GPT, and ALP). Introduction: Gabapentin is an anti-convulsant that is also used off-label to treat neuropathic pain. It is not metabolized by the liver, and there have been few reports of hepatotoxity associated with it. We present a rare case of gabapentin-induced hepatotoxicity occurring in a young male. Case Description/Methods: A 41-year-old male with an extensive past medical history including type 1 While gabapentin has various side effects and precautions, it typically doesn’t affect the liver, although there are rare cases when it might. We’ve got everything you need to know below. Learn about the potential effects of Gabapentin on your liver and kidneys. Find out if it is safe to use and how to protect your organs while taking this medication. Antiepileptic drugs (AEDs) are a common cause of drug induced liver injury (DILI). Over the last few decades, several newer AEDs were approved for marketing in the United States, and they are increasingly prescribed for indications other than Discussion: Gabapentin induced liver injury is rare with few reported cases, many of which did not exclude other etiologies. In this case, the key elements of diagnosing DILI were met including gabapentin initiation closely preceding liver injury, other etiologies excluded, and discontinuation of gabapentin leading to improvement. Gabapentin is not metabolized by the liver. Instead, it is excreted unchanged in your kidneys after circulating in your blood. Gabapentin affects nerves and chemicals in your body that are involved in some types of pain and in seizures. Key takeaways: Gabapentin (Neurontin, Horizant, Gralise) usually isn’t bad for your liver or kidneys. In most cases, it has no harmful effect on these organs. In rare instances, gabapentin can cause DRESS (drug reaction with eosinophilia and systemic symptoms) syndrome. A drug-induced liver injury is one of the most common causes of acute liver failure. While acetaminophen is the most common etiology, other offending medications include amoxicillin-clavulanic acid, amiodarone, isoniazid, and fluoroquinolones to name a few. Gabapentin, a gamma-aminobutyric acid (GAB Understanding Gabapentin Effects When it comes to understanding how Gabapentin affects the liver, it is important to consider both the potential risks and the benefits of using this medication. Gabapentin is commonly prescribed to treat conditions such as epilepsy, neuropathic pain, and restless leg syndrome. However, it is essential to be aware that Gabapentin can have an impact on liver Gabapentin is a unique anticonvulsant that is used as adjunctive therapy in management of epilepsy and for neuropathic pain syndromes. Therapy with gabapentin is not associated with serum aminotransferase elevations, but several cases of clinically apparent liver injury from gabapentin have been reported. Liver and renal functions were impaired by gabapentin; where hepatotoxicity was associated by an imbalance in the redox status. However, magnesium only elevated blood urea nitrogen (BUN). Ultimately, understanding the potential effects of gabapentin on your liver is crucial, especially if you have pre-existing liver conditions. While the research suggests that is gabapentin bad for your liver isn't a common concern, it's always wise to discuss your health history and any medications you're taking with your doctor. Gapentin is not metabolized by the liver, and its effects on the liver and kidneys are similar to previous studies. In rare cases, gabapentin can cause DRESS (drug reaction with eosinophilia and systemic symptoms). Am J Ther. 2022 Nov-Dec;29 (6):e751-e752. doi: 10.1097/MJT.0000000000001208. Epub 2020 Jun 5. 1 Internal Medicine, SUNY Upstate Medical University, Syracuse, NY. 2 Gastroenterology, SUNY Upstate Medical University, Syracuse, NY. Gabapentin lacks liver metabolism; the mechanism by which it produces liver injury is still unknown; however, there are reports of hepatotoxicity associated with its administration, so its use must be individualized for each patient. Gabapentin enacarbil is a long acting form of gabapentin that is used for restless leg syndrome and for painful postherpetic neuropathy. Gabapentin enacarbil and gabapentin are associated with a low rate of transient serum enzyme elevations during treatment and with rare instances of clinically apparent liver injury. Gabapentin is an uncommon cause of DILI reported to cause a hepatocellular, cholestatic, or mixed picture of liver injury. Given the limitations of prior cases, we feel our report most closely ties gabapentin use to the resultant transaminase elevation. Question I have a patient with trigeminal neuralgia who was taking 1600 mg of gabapentin and had serious elevations of liver function tests (aspartate transaminase 258 U/L, alanine transaminase This article delves deep into the relationship between gabapentin and liver health, exploring mechanisms of action, potential side effects, case studies, and recommendations for monitoring liver function during treatment.
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