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We evaluated the optimal preemptive dose of gabapentin for postoperative pain relief after single-level lumbar diskectomy and its effect on fentanyl consumption during the initial 24 hours in a randomized, double-blinded, placebo-controlled study in 100 patients with American Society of Anesthesiologists physical status I and II. It has been argued that postoperative pain treatment should be “procedure-specific”, since different analgesics may have specific effects dependent on the surgical procedure. The aim of the present subgroup analysis was to compare the beneficial and harmful effects of perioperative gabapentin treatment in different surgical procedures. SUMMARY Gabapentin (NeurontinTM) has gained significant interest as part of a multi-modal pain management strategy for the control of acute pain. There has been considerable variation in both the dose and the regimen used in recent clinical trials. Most have relied on pre-operative dosing and have utilized a single dose of 300 to 1200 mg. Higher doses seem to show a decrease in postoperative Gabapentin is an anticonvulsant that has antinociceptive and antihyperalgesic properties (Rose and Kam, 2002). It has a well-established role in the treatment of chronic pain (Wiffen et al., 2005). In particular, it is effective for neuropathic pain (Bennett and Simpson, 2004), diabetic neuropathy (Backonja et al., 1998), postherpetic neuralgia (Rowbotham et al., 1998) and complex regional We would like to show you a description here but the site won’t allow us. This review evaluated the efficacy and tolerability of peri-operative gabapentin administration to control acute post-operative pain. Peri-operative gabapentin administration was found to be effective in reducing pain scores, opioid requirements and opioid-related adverse effects in the first 24 hours after surgery. Given the significant differences between the studies and the possibility of This randomized clinical trial evaluates the effects of perioperative administration of gabapentin on postoperative pain resolution and time to cessation of opioid use. Conclusion: The preoperative administration of gabapentin appears to be an effective strategy for enhancing postoperative pain control and reducing opioid use in orthopedic patients undergoing spinal anesthesia. Further studies are necessary to determine the optimal dosing regimen and long-term effects of gabapentin in this setting. Abstract Background: Perioperative pain treatment often consist of combinations of non-opioid and opioid analgesics, 'multimodal analgesia', in which gabapentin is currently used. The aim was to document beneficial and harmful effects of perioperative gabapentin treatment. Abstract Background Gabapentin is an antiepileptic drug used in a variety of chronic pain conditions. Increasing numbers of randomized trials indicate that gabapentin is effective as a postoperative analgesic. This procedure-specific systematic review aims to analyse the 24-hour postoperative effect of gabapentin on acute pain in adults. Methods Medline, The Cochrane Library and Google Scholar Abstract BACKGROUND: Gabapentin, an anticonvulsant, has recently been suggested as an effective postoperative ‘analgesic’ agent. The objective of the present study was to examine the analgesic effectiveness, opioid-sparing effects and side effects associated with the use of gabapentin in a perioperative setting. METHODS: Following the Quality of Reporting of Meta-analyses recommendations Gabapentin 250 mg is statistically superior to placebo in the treatment of established acute postoperative pain, but the NNT of 11 for at least 50% pain relief over 6 hours with gabapentin 250 mg is of limited clinical value and inferior to commonly used analgesics. Key takeaways Some doctors will prescribe gabapentin either before or after surgery to help manage postsurgical pain and reduce the need for opioid painkillers. Gabapentin may cause side effects, and it can also cause abuse or dependence. It may also cause withdrawal, especially in patients who stop treatment abruptly. Opioids are another common treatment for postoperative pain, but they also Selection criteria: Single oral dose, randomised, double-blind, placebo-controlled trials of gabapentin for relief of established moderate to severe postoperative pain in adults. Data collection and analysis: Studies were assessed for methodological quality and data extracted by two review authors independently. Key takeaways Some doctors will prescribe gabapentin either before or after surgery to help manage postsurgical pain and reduce the need for opioid painkillers. Gabapentin may cause side effects, and it can also cause abuse or dependence. It may also cause withdrawal, especially in patients who stop treatment abruptly. Opioids are another common treatment for postoperative pain, but they also A number of systematic reviews with meta-ana-lyses on gabapentin for post-operative pain treatment have previously been published.166– 170 Most reported a more favorable outcome for gabapentin treatment, including reduced opioid consumption, pain levels, and opioid-related adverse effects, than the present review. SUMMARY Gabapentin (NeurontinTM) has gained significant interest as part of a multi-modal pain management strategy for the control of acute pain. There has been considerable variation in both the dose and the regimen used in recent clinical trials. Most have relied on pre-operative dosing and have utilized a single dose of 300 to 1200 mg. Higher doses seem to show a decrease in postoperative Abstract Background: Perioperative pain treatment often consist of combinations of non-opioid and opioid analgesics, 'multimodal analgesia', in which gabapentin is currently used. The aim was to document beneficial and harmful effects of perioperative gabapentin treatment. Gabapentin (1-aminomethyl-cyclohexaneacetic acid) is an amino acid that has the structure of the neurotransmitter γ-aminobutyric acid (GABA). It is a novel drug used for the treatment of postoperative pain with antihyperalgesic properties and a Pain management after total knee arthroplasty (TKA) varies and has been widely studied in recent years. Some randomized controlled studies have carried out to evaluate the effects of gabapentin on pain relief after TKA. However, no solid result was
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