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Abstract Objective: Gabapentin (GBP) is an anticonvulsant medication that is also used to treat restless legs syndrome (RLS) and posttherapeutic neuralgia. GBP is commonly prescribed off-label for psychiatric disorders despite the lack of strong evidence. However, there is growing evidence that GBP may be effective and clinically beneficial in both psychiatric disorders and substance use Gabapentin, a prescription medication approved for the treatment of seizures and neuralgia, is often prescribed off-label for substance use treatment, mental health problems, and pain. Emerging reports also suggest it is misused for the purpose of Abstract Gabapentin is effective for the treatment of alcohol dependence and can be used for treating anxiety, insomnia, headaches, and/or pain in patients who have comorbid substance use disorders (SUDs) or who are at high risk of substance abuse. Deaths from unintentional drug overdoses are increasing, are the leading cause of injury death in the United States, and are mostly attributable to Abstract Objective This article reviews evidence-based psychiatric uses of gabapentin, along with associated risks. Method of Research An extensive literature review was conducted, primarily of articles searchable in PubMed, relating to psychiatric uses, safety, and adverse effects of gabapentin. Results Evidence supports gabapentin as a treatment for alcohol withdrawal and alcohol use The gabapentinoid drugs, gabapentin and pregabalin, are first-line treatments for neuropathic pain. The epidemics of chronic pain and opioid misuse have given rise to the widespread use of non-opioid drugs such as the gabapentinoids for treatment. Unfortunately, the widespread use of gabapentinoid drugs has resulted in reports of misuse and abuse. Additionally, gabapentin has been prescribed to manage opioid withdrawal symptoms (which may include pain), or for co-occurring mental health disorders in people with opioid use disorder.9 These, along with other potential applications, highlight the promising role of gabapentin in substance use disorder treatment. Dear Editor: Substance use disorders frequently coexist with and complicate the treatment of mood and anxiety disorders. Gabapentin is one of the most commonly prescribed off-label medications in psychiatric settings. 1 Despite limited evidence, it has been used frequently in the treatment of mood and anxiety disorders in patients with comorbid substance use disorders. There is growing concern Since its market release, gabapentin has been presumed to have no abuse potential and subsequently has been prescribed widely off-label, despite increasing reports of gabapentin misuse. This review estimates and describes the prevalence and effects Gabapentin is an anti-epileptic drug, also called an anticonvulsant. It is used to treat some types of seizures and nerve pain caused by shingles. High-dose gabapentin use can be predictive of opiate misuse disorder. This study investigated the relationship between gabapentin use and dose with substance use disorders prior to inpatient mental health treatment. Read on to find out more. Gabapentin is a medication that prevents seizures and pain, but like any medicine, it can be misused. Learn what can happen if you misuse gabapentin and have a substance use disorder. While the nation is addressing an opioid crisis, other pain-relieving drugs share the potential for abuse as well. Gabapentin is approved to prevent and control partial seizures, relieve postherpetic neuralgia after shingles and moderate-to-severe restless legs syndrome. Learn what side effects to watch for, drugs to avoid while taking gabapentin, how to take gabapentin and other important questions and answers. Gabapentin is available in both branded and generic forms. Objective: Gabapentin (GBP) is an anticonvulsant medication that is also used to treat restless legs syndrome (RLS) and posttherapeutic neuralgia. GBP is commonly prescribed off-label for psychiatric disorders despite the lack of strong evidence. However, there is growing evidence that GBP may be effective and clinically beneficial in both psychiatric disorders and substance use disorders CATR Verdict: In patients with substance use disorders, avoid prescribing gabapentin to patients with active or recent opioid use disorder. However, gabapentin is often helpful as an adjunctive agent in the treatment of AUD, and for anxiety and insomnia in patients who might overuse addictive drugs like benzodiazepines. This case-control study with crossover analysis assesses the differences between patients receiving and not receiving gabapentin alongside buprenorphine in the treatment of opioid use disorder and the drug-related poisoning risk associated with gabapentin. More clinical trials with larger patient populations are needed to support gabapentin's off-label use in psychiatric disorders and substance use disorders. It is worth noting that numerous clinical studies that are discussed in this review are open-label trials, which are inherently less rigorously analyzed. Key Points The gabapentinoids pregabalin and gabapentin have a potential for being abused and misused, which could result in substance dependence and intoxications. Individuals with a history of psychiatric disorders or substance use disorder seem to be at high risk for misuse and abuse. More clinical trials with larger patient populations are needed to support gabapentin’s off-label use in psychiatric disorders and substance use disorders. It is worth noting that numerous clinical studies that are discussed in this review are open-label trials, which are inherently less rigorously analyzed. The federal government does not classify gabapentin as a controlled substance, but several states have changed its status to help curb abuse. What is gabapentin used for? Gabapentin is a prescription anticonvulsant medicine approved to treat partial seizures and for the management of postherpetic neuralgia (shingles nerve pain) in adults. Gabapentin is an anticonvulsive medication that received approval from the US Food and Drug Administration (FDA) in 1993 and has been available in generic form in the USA since 2004. Gabapentin was originally used as a muscle relaxant and an anti-spasmodic. However, it was later discovered that gabapentin has the potential of an anticonvulsive medication and can be used as an adjunct to more
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