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This proof-of-concept study assessed the efficacy of gabapentin placebo as a novel treatment for reducing marijuana use and withdrawal symptoms in a group of treatment-seeking unpaid outpatient volunteers with cannabis dependence. In nontreatment-seeking cannabis users, gabapentin shared interoceptive and subjective effects with THC, and an early pilot clinical trial in treatment-seeking patients found that gabapentin treatment decreased urinary THC metabolite levels, self-reported cannabis use, craving and depression, and improved performance on tests of executive function. A proof-of-concept randomized controlled study of gabapentin: Effects on cannabis use, withdrawal and executive function deficits in cannabis-dependent adults. Neuropsychopharmacology 2012 Jun; 37:1689. Many users have asked, “is it safe to smoke marijuana while taking gabapentin?” This article explores the current research and understanding between gabapentin and cannabis. The Food and Drug Administration (FDA) has granted Fast Track designation to PP-01 (nabilone/gabapentin) for the mitigation of cannabis withdrawal symptoms in patients with cannabis use disorder. DEPENDENCE, WITHDRAWAL STATES AND CLINICAL MANAGEMENT Description Cannabis withdrawal refers to symptoms that occur after abrupt cessation or significant reductions in the use of cannabis products containing Δ 9 -tetrahydrocannabinol (THC), the main psychoactive component in cannabis. These symptoms occur most often in regular and heavy cannabis users and the most common symptoms are anxiety In addition to decreasing symptoms of withdrawal, gabapentin has been found to reduce quantitative THC urine levels, a marker for overall cannabis use, and improve cognitive functioning in cannabis-dependent adults (Mason et al., 2012). Anticonvulsants: Some anticonvulsant medications, such as gabapentin (Neurontin) and pregabalin (Lyrica), have been used to manage cannabis withdrawal symptoms. These medications are thought to help with symptoms such as anxiety, irritability, and sleep disturbances by stabilizing nerve activity in the brain. We would like to show you a description here but the site won’t allow us. The primary hypotheses are that gabapentin will decrease symptoms of cannabis withdrawal, specifically affect and sleep, and decrease excessive use significantly more than placebo. A further hypothesis is that, through its effects on cannabis withdrawal and use, gabapentin will decrease cannabis-related impairment in cognitive functioning. The purpose of the current study was to determine the efficacy of GBP on attenuating THC withdrawal in mice, using an array of tests targeting withdrawal-induced and withdrawal-suppressed behaviors. Cannabis withdrawal is a well‐characterized phenomenon that occurs in approximately half of regular and dependent cannabis users after abrupt cessation or significant reductions in cannabis products that contain Δ9‐tetrahydrocannabinol (THC). This Gabapentin (GBP) synergizes with cannabinoid agonism in neuropathic pain models, substitutes for Δ 9 -tetrahydrocannabinol (THC) in drug discrimination procedures, and reduced withdrawal symptoms in an outpatient clinical trial. Gabapentin has been found to interact with THC, producing a synergistic effect on reducing mechanical and cold allodynia in a mouse neuropathic pain model, and attenuating somatic signs of precipitated THC withdrawal in mice 3, 6. Gabapentin (GBP) synergizes with cannabinoid agonism in neuropathic pain models, substitutes for Δ 9 -tetrahydrocannabinol (THC) in drug discrimination procedures, and reduced withdrawal symptoms in an outpatient clinical trial. Gabapentin (GBP) attenuates THC withdrawal-depressed progressive-ratio (PR) performance. Mice were trained on a PR 2 schedule of reinforcement. (A) Acute GBP (10 and 50 mg/kg, i.p.) dose-dependently increased break point (* p < .05 vs. 0 mg/kg). (B) After THC or vehicle was administered for 5.5 days, mice were pretreated with GBP (10 or 50 mg/kg, i.p.) or vehicle, and all mice were A proof-of-concept randomized controlled study of gabapentin: effects on cannabis use, withdrawal and executive function deficits in cannabis-dependent adults. Neuropsychopharmacology. 2012;37 (7):1689-1698. This POC pilot study provides preliminary support for the safety and efficacy of gabapentin for treatment of cannabis dependence that merits further study, and provides an alternative conceptual framework for treatment of addiction aimed at restoring homeostasis in brain stress systems that are dysregulated in drug dependence and withdrawal. This proof-of-concept study assessed the efficacy of gabapentin vs placebo as a novel treatment for reducing marijuana use and withdrawal symptoms in a group of treatment-seeking unpaid outpatient Cannabis withdrawal: Epidemiology, clinical features, diagnosis, and treatment.
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