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Frequent use of common pain drug linked to increase in dementia and cognitive decline, study suggests. The study analyzed gabapentin prescription patterns of orthopedic surgeons from 2013 to 2021 recorded in annual Medicare Part D Public Use Files across the fifty states and Washington DC. Datasets were filtered to only include orthopedic providers. Gabapentin prescriptions were grouped based on state of practice for each surgeon per year for total gabapentin claims, supply in days, and Here's who gabapentin was originally approved for, what it's used for today and why it's becoming a drug of increasing concern for abuse and misuse. However, a clear pattern emerged in the middle-aged and older groups. Individuals aged 35-49 prescribed gabapentin exhibited a more than twofold increase in the risk of both dementia (2.44 times higher) and MCI (3.50 times higher). This elevated risk persisted in the 50-64 age bracket, with gabapentin exposure linked to a 2.28-fold increase in dementia incidence and a 2.22-fold increase in MCI Risks also rose the more often patients use gabapentin. Those with 12 or more prescriptions were 40% more likely to develop dementia and 65% more likely to develop MCI than those with fewer prescriptions.. “Our findings indicate an association between gabapentin prescription and dementia or cognitive impairment within 10 years. Moreover, increased gabapentin prescription frequency correlated Receiving six or more prescriptions of the drug gabapentin for low back pain is associated with significantly increased risks of developing dementia and mild cognitive impairment (MCI)--29% and 85 Compared to those not exposed to gabapentin, Veterans prescribed gabapentin were slightly younger, more likely to have type 2 diabetes, depression, smoke, have post-traumatic stress disorder, and alcohol use disorder. The median dose of gabapentin was 444 mg/day (IQR, 148–961), with 26% of prescriptions greater than 900 mg/day. Having originally been developed as an anti-seizure medication, gabapentinoids include gabapentin and pregabalin, which are now prescribed primarily for neuropathic pain, seizures and anxiety, but also for fibromyalgia, restless legs syndrome and complications of MS (Chan et al, 2023). First introduced in the UK and the US in 1993, the number of doses of pregabalin and gabapentin taken daily Gabapentin is an anticonvulsant medication prescribed for a variety of conditions. Learn about its uses, side effects, and what you should know if you've been prescribed this medication. A large U.S. medical records study has found that adults prescribed gabapentin six or more times for chronic low back pain face significantly higher risks of dementia (29%) and mild cognitive impairment (85%) within 10 years. People with prior gabapentin use, dementia, epilepsy, stroke, or cancer were excluded from the study. Receiving six or more prescriptions of the drug gabapentin for low back pain is associated with significantly increased risks of developing dementia and mild cognitive impairment (MCI)—29% and Frequent use of gabapentin for back pain may raise the risk of dementia by 29% and mild cognitive impairment by 85%, new study finds. Gabapentin (Neurontin) prescriptions for chronic low back pain were linked with an increased risk of dementia and cognitive impairment, especially in younger people, an analysis of U.S. healthcare Learn about Gabapentin Enacarbil, its uses for nerve pain and restless legs syndrome, dosage guidelines, side effects, and how it compares to Gabapentin. Gabapentin is an anticonvulsive medication that received approval from the US Food and Drug Administration (FDA) in 1993 and has been available in generic form in the USA since 2004. Gabapentin was originally used as a muscle relaxant and an anti-spasmodic. However, it was later discovered that gabapentin has the potential of an anticonvulsive medication and can be used as an adjunct to more The off-label use of gabapentinoids is a significant yet understudied issue, particularly in Nepal. This study aimed to address the research gaps by analyzing the prescribing patterns of gabapentin and pregabalin at a tertiary care hospital in Nepal. New data suggest an association between gabapentin for chronic back pain and increased risk of cognitive impairment, although experts urge caution in drawing any firm conclusions. Gabapentin and pregabalin are widely used in the management of neuropathic pain though their prescribing patterns, effectiveness, and safety profiles remain topics of ongoing research. This retrospective chart review analyzed the prevalence of gabapentinoid use in a chronic pain clinic over a one-year period from May 1, 2023, to April 30, 2024. Gabapentin is approved to prevent and control partial seizures, relieve postherpetic neuralgia after shingles and moderate-to-severe restless legs syndrome. Learn what side effects to watch for, drugs to avoid while taking gabapentin, how to take gabapentin and other important questions and answers. Gabapentin is available in both branded and generic forms.
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