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Recent attention to off-label use of gabapentin is largely attributable to a renewed interest in this medication as a chronic pain treatment in the wake of the opioid epidemic. However, recent case reports suggest that gabapentin is increasingly being prescribed for psychiatric indications, predominantly anxiety and depression (7, 8). Conflicting evidence suggests that gabapentin’s use in Two new anticonvulsants, lamotrigine and gabapentin, have been used increasingly for bipolar disorder in the past several years. Despite this array of options, bipolar disorder remains a difficult disorder to treat. Some subtypes, such as those characterized by rapid cycling or mixed episodes, have been especially resistant to lithium treatment. Gabapentin is commonly used off-label in the treatment of psychiatric disorders with success, failure, and controversy. A systematic review of the literature was performed to elucidate the evidence for clinical benefit of gabapentin in psychiatric Gabapentin is commonly used off-label in the treatment of psychiatric disorders with success, failure, and controversy. A systematic review of the literature was performed to elucidate the evidence for clinical benefit of gabapentin in psychiatric disorders. Key takeaways: Gabapentin is a medication that’s used to treat seizures, nerve pain from shingles, and restless leg syndrome. Despite previous marketing claims, there’s no evidence that gabapentin is a good treatment for bipolar disorder. The best treatment for bipolar disorder is therapy and a combination of other medications. These include mood stabilizers, anticonvulsants, and Subject terms: Neuroscience, Bipolar disorder Introduction The gabapentinoids comprise gabapentin and pregabalin. Gabapentin is licensed for use in the USA for the treatment of focal seizures and post-herpetic neuralgia [1] and in the UK for focal seizures and peripheral neuropathic pain [2]. Gabapentin is a nerve pain medication and anticonvulsant that has proven to be effective for people who have hard-to-treat depression or other mood disorders. with bipolar I, bipolar II, and treat-ment-resistant depression.3 Thus, the new FDA approvals for bipolar mania for quetiapine and ziprasidone and pending for aripiprazole mean the possibility of adding new options to the treatment formula for bipolar spectrum disorders, including some with less risk of weight gain and per-haps diabetes.10 Any Gabapentin was significantly more effective than lamotrigine and carbamazepine in reducing depressive symptoms on the Minnesota Multiphasic Personality Inventory-2 (MMPI-2) depression subscale (50 Abstract Despite its prevalence and disease burden, several chasms still exist with regard to the pharmacotherapy of bipolar disorder (BD). Polypharmacy is commonly encountered as a significant proportion of patients remain symptomatic, and the management of the depressive phase of the illness is a particular challenge. Gabapentin and pregabalin have often been prescribed off-label in spite of Unfortunately, gabapentin does not demonstrate efficacy in randomized trials for bipolar disorder and current treatment guidelines do not emphasize its use. Despite of the lack of evidence, reviews of gabapentin prescribing patterns in the United States show that this medication is still being used with alarming frequency for bipolar disorder. This article reviews evidence-based psychiatric uses of gabapentin, along with associated risks. An extensive literature review was conducted, primarily of articles searchable in PubMed, relating to psychiatric uses, safety, and adverse effects of Gabapentin may help with some symptoms of bipolar disorder, but there’s limited evidence supporting its effectiveness, and it’s not FDA approved for bipolar. How-ever, it does provide initial pilot data in the same sample regarding the possible effectiveness of gabapentin in bi-polar disorder type I, other parts of the bipolar spectrum (bipolar disorder type II and NOS), and unipolar major depressive disorder. Gabapentin For Mental Health: Uses And Benefits When it comes to the treatment of mental health disorders like bipolar disorder and depression, many different medications are available, each with unique effects on people, and gabapentin is one of them. Gabapentin was explicitly developed to treat seizures but now has become a valuable option in mental health care. Its ability to provide relief Gabapentin may be a useful drug for the add-on treatment of bipolar patients with poor response to other mood stabilizers. Gabapentin may improve depressive residual symptoms such as irritability, social withdrawal or anxiety. These results should be confirmed in randomized clinical trials. Abstract Background: Gabapentin, a new anti-epileptic agent, has been anecdotally reported to be effective in the treatment of mania. We systematically assessed the response rate in bipolar patients being treated adjunctively with gabapentin for manic symptoms, depressive symptoms, or rapid cycling not responsive to standard treatments. Explore gabapentin's role in mental health treatment, including its uses, benefits, and potential risks. Learn about dosage, effectiveness, and side effects. Using Gabapentin as a Treatment Option In recent years, gabapentin has been studied as a potential adjunctive treatment for bipolar disorder. Studies have shown that gabapentin can help reduce symptoms of depression and anxiety in patients with bipolar disorder, particularly when used in conjunction with other medications.
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