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Effect of Gabapentin versus Pregabalin on Pain Intensity in Adults with Chronic Sciatica- Prospective Observational Study. International Journal of Current Medical and Applied sciences; 2024, 43(1), 05-08. In patients with chronic sciatica, gabapentin was associated with a greater reduction in leg pain intensity and fewer side effects compared with pregabalin, according to a study published in JAMA Gabapentin and pregabalin do not cure sciatica; they help manage the symptoms by reducing nerve pain. The underlying cause of sciatica, such as a herniated disc, often requires additional treatment. Keywords: Gabapentin, Pregabalin, Sciatica, Pain, Clinical trial, Protocol Background Sciatica or sciatic neuralgia, a common form of lumbosacral radiculopathy, is characterised by low back pain which radiates to the leg and which may be accompanied by sensory loss, motor weakness and/or reflex abnormalities. A recently published 17-week single-center, blinded, crossover study found that gabapentin was superior to pregabalin in terms of reducing leg pain intensity and had fewer adverse effects. Study limitations hinder broad application of these findings but represent the best available evidence regarding the treatment of chronic sciatica. Sciatica is a disabling condition characterized by radiating posterior or posterolateral leg pain that is sometimes accompanied by back pain, sensory loss, weakness, or reflex abnormalities. Evidence regarding medical treatment is limited. Both gabapentin and pregabalin have been widely used to treat neuropathic pain including sciatica. The efficacy for sciatica and side effects of both Abstract Importance: Optimal pharmacologic treatment for chronic sciatica (CS) is currently unclear. While gabapentin (GBP) and pregabalin (PGB) are both used to treat CS, equipoise exists. Nevertheless, pharmaceutical regulation authorities typically subsidize one drug over the other. This hinders interchange wherever the favored drug is either ineffective or ill-tolerated. Note that pregabalin is currently approved for treating generalized anxiety disorder (GAD) in Europe, but not in the United States. Continue reading for an in-depth comparison of pregabalin versus gabapentin, including an analysis of their respective uses, proven efficacy, dosing regimens, side effects, and more. Read on to learn more about which sciatic medications may help to alleviate nerve pain, including medications like Lyrica and gabapentin. Effectiveness and Side Effects of Gabapentin and Pregabalin for Sciatica Pain Sciatica pain originates from the compression, irritation, or damage of the sciatic nerve, resulting in aching in the lower back that extends through the leg. Gabapentin vs pregabalin: which is right for you? Our guide breaks down the key similarities and differences of these medications to help understand options. Topiramate (Topamax) and pregabalin (Lyrica) should not be used in patients with sciatica. (SOR: B, based on small RCTs.) All of these medications have adverse effects. Whilst pregabalin (PGB) and gabapentin (GBP) are both used to treat neuropathic pain, their relative role in sciatica is unclear. Our aim was to extensively review the roles of PGB and GBP in treating sciatica. The efficacy, side effects (SE) profile and cost of PGB and GBP in neuropathic pain state Hailshadow / Getty Images Differences: Pregabalin vs. Gabapentin One of the primary differences between gabapentin and pregabalin is that the FDA has approved both drugs for some of the same indications but also different ones. The chart below shows the indications for which the FDA approves gabapentin and pregabalin to treat: Sciatica can be disabling, and evidence regarding medical treatments is limited. Pregabalin is effective in the treatment of some types of neuropathic pain. This study examined whether pregabalin m Gabapentin is an anticonvulsant used to treat nerve related back pain, such as sciatica. Learn more about how gabapentin is used in sciatica treatment. This randomized clinical trial assesses the effect of gabapentin vs pregabalin in leg pain intensity and compares adverse events among adults with chronic sciatica. Robertson K, Marshman LAG, Plummer D, Downs E. Effect of Gabapentin vs Pregabalin on Pain Intensity in Adults With Chronic Sciatica: A Randomized Clinical Trial. Robertson K, Marshman LAG, Plummer D, Downs E. Effect of Gabapentin vs Pregabalin on Pain Intensity in Adults WIth Chronic Sciatica: A Randomized Clinical Trial. Sciatica is a symptom rather than a specific diagnosis 4 and is used broadly to refer to pain that radiates along the path of the sciatic nerve. 5 The commonest cause of sciatica is impingement of lumbosacral nerve roots, as they emerge from the spinal canal, by a herniated intervertebral disc (fig 1).
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