I’ve been on Gabapentin for roughly 7 months, my doses have varied from 600mg-1,200/day and I get some nerve pain relief, and helps me sleep, but little to no benefit for treating my anxiety. I’m curious if anyone has had a better experience managing anxiety with taking Pregabalin? Any pros, cons? Pregabalin (Lyrica) and gabapentin (Neurontin) are both approved to treat nerve pain. How are they different, and which one is preferred? Compare both meds here. I personally have found the Gabapentin to be a game changer! In peri and my anxiety also shot up like crazy, seemingly out of nowhere and for no reason. Haven't tried Lyrica but will stick with the Gabapentin for now. 300mg two times a day. My bestie had terrible side effects with gabapentin, but Lyrica is great for them. I'm tapering down on gabapentin (from 2700 daily to 600) and starting Lyrica. After almost two weeks it seems positive for overall pain management, but my diabetic neuropathy related nerve pain is noticeably worse. Mountain-Pace5297 Pregabalin vs gabapentin for severe anxiety? Wondering what one is best for severe anxiety and agoraphobia out of the two, and also which has the lowest side effects? I heard pregabalin usually works better for anxiety but both can greatly impact cognition (people seem to feel less intelligent while taking them). You may be a good candidate for phenelzine (Nardil). This is a very special MAOI with exceptionally powerful anti-anxiety properties. It is sometimes considered the gold standard for social anxiety. Tranylcypromine (Parnate) can also be extremely Welcome to /r/gabapentin, here we primarily discuss issues pertaining to the medical, prescribed use of Gabapentin, Lyrica and Phenibut, as well as other Gaba related drugs. This IS NOT the subreddit for discussion of how to get high or otherwise abuse GP. If you're looking for information on how to get high or potentiate GP, you'll want to head over to /r/gabagoodness they'll welcome you! Yes, well, it does interest me, gabapentin vs pregabalin because I have a decent number of folks on gabapentin, and it maybe seems to help 10-20% for symptom reduction. I also feel, although obviously can't prove, that for many it might be a placebo effect, just knowing there's 'something' they are taking for their anxiety. Contact Our Team Gabapentin and Lyrica are both used to treat nerve pain, seizures, and anxiety, but they have key differences in potency, absorption, and risk for misuse. While they can be beneficial when taken correctly, they also have the potential for dependency and withdrawal symptoms. 17 votes, 55 comments. hello there! i've been taking gabapentin for around 2 or 3 years, originally for my anxiety (which it did nothing for) but we The gabapentinoids, gabapentin, and pregabalin, target the α2δ subunits of voltage-gated calcium channels. Initially licensed for pain and seizures, they have become widely prescribed drugs. Many of these uses are off-label for psychiatric Pregabalin and gabapentin are gabapentinoids used to manage anxiety disorders such as GAD, SAD, and PTSD. Pregabalin (Lyrica) exhibits higher affinity for alpha2-delta ligands than gabapentin (Neurontin), resulting in more potent activity. Clinical evidence suggests that pregabalin may offer superior efficacy compared to gabapentin, with better symptom reduction and response rates. Both agents Pharmacokinetic differences between pregabalin and gabapentin could explain a difference in efficacy. Industry investment in the pivotal controlled trials necessary to attain regulatory approval of gabapentinoids for anxiety disorders seems unlikely to happen, and consequently their use for this purpose will continue to be off-label. Note that pregabalin is currently approved for treating generalized anxiety disorder (GAD) in Europe, but not in the United States. Continue reading for an in-depth comparison of pregabalin versus gabapentin, including an analysis of their respective uses, proven efficacy, dosing regimens, side effects, and more. Has anyone compared the two? Gabapentin doesn't do much for my anxiety. Is it worth trying to get my doc to swap me to Lyrica? For people who have made the switch, any tips on how to convince your doc to make the change? I was thinking to pull the whole "id prefer to take one pill of Lyrica once a day instead of having to remember to take 3 Gabapentins with me, everywhere I go, to dose 3 x a GABAGoodness is devoted to the discussion of all GABAergics, Gabapentnoids and VDCC inhibitors such as Pregabalin, Gabapentin, Phenibut, Carisoprodol, GHB, Benzodiazepines, Barbiturates, and more! This is a great place to ask general or recreational questions, get harm reduction advice, or share your experience with withdrawal syndromes. For professional counseling, ask your psychiatrist or Pregabalin is effective in reducing symptoms of anxiety, has approval for treatment of GAD in Europe, and also likely effective in other anxiety disorders. 4 Alcohol use disorder: Gabapentin and pregabalin have been shown to have some efficacy in alcohol withdrawal and reducing drinking but evidence is limited. Adjunct in bipolar disorder?? Gabapentin is more likely than Lyrica to cause side effects such as difficulty speaking, fever, an increased risk of viral infections, unusual eye movements, or jerky movements Lyrica is absorbed faster and starts working more quickly than gabapentin. Gabapentin was slightly better as far as helping with anxiety, but they are about the same as far as pain relief. I switched because I was developing a tolerance to the gabapentin after being on it for years. I sometimes will do gabapentin first because it’s cheaper in the US and less risk of weight gain, which can be problematic on pregabalin. If they don’t like gabapentin I’ll try pregabalin. I had an older guy fail SRI’s and was taking lorazepam daily and we’ve been able to cut it down to ~2x/week with just pregabalin. YMMV. As the other poster said, it does have good evidence and its
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