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Conclusions Gabapentin is an uncommon cause of DILI reported to cause a hepatocellular, cholestatic, or mixed picture of liver injury. Given the limitations of prior cases, we feel our report most closely ties gabapentin use to the resultant transaminase elevation. A drug-induced liver injury is one of the most common causes of acute liver failure. While acetaminophen is the most common etiology, other offending medications include amoxicillin-clavulanic acid, amiodarone, isoniazid, and fluoroquinolones to name a few. Gabapentin, a gamma-aminobutyric acid (GAB Gabapentin (Neurontin) is generally not harmful to the liver or kidneys, but in rare cases, it can cause DRESS syndrome. It is not metabolized by the liver and is excreted unchanged in the kidneys after circulation. Gabapentin affects nerves and chemicals in your body that are involved in some types of pain and in seizures. There is insufficient data to estimate incidence for these or establish whether gabapentin is the sole cause of elevated liver function tests, notes Pfizer. Gabapentin is generally considered safe for the liver, but rare cases of liver damage have been reported. Gabapentin, a medication primarily used to treat nerve pain and seizures, has gained popularity for its effectiveness and relatively mild side effects. However, concerns about its impact on liver health have surfaced among patients and healthcare providers. Understanding whether gabapentin Gabapentin enacarbil is a long acting form of gabapentin that is used for restless leg syndrome and for painful postherpetic neuropathy. Gabapentin enacarbil and gabapentin are associated with a low rate of transient serum enzyme elevations during treatment and with rare instances of clinically apparent liver injury. Gabapentin is a unique anticonvulsant that is used as adjunctive therapy in management of epilepsy and for neuropathic pain syndromes. Therapy with gabapentin is not associated with serum aminotransferase elevations, but several cases of clinically apparent liver injury from gabapentin have been reported. Gapentin is not metabolized by the liver, and its effects on the liver and kidneys are similar to previous studies. In rare cases, gabapentin can cause DRESS (drug reaction with eosinophilia and systemic symptoms). Prior lab review showed liver enzymes within normal limits until one month prior to admission, when his ALP was 851. He started taking gabapentin, without introduction of any other medications, one month prior to the initial rise in ALP . Evaluation for viral, inherited, and metabolic causes of liver disease were negative. The bad effects of gabapentin in a study come in line with previous studies, and even high doses of gabapentin (400mg/kg) for 30 days do not produce deleterious adverse effects on the liver nor the haematological parameters. Liver enzymes returned to normal after gabapentin was discontinued. Introduction: Gabapentin is an anti-convulsant that is also used off-label to treat neuropathic pain. It is not metabolized by the liver, and there have been few reports of hepatotoxity associated with it. We present a rare case of gabapentin-induced hepatotoxicity occurring in a young male. Case Description/Methods: A 41-year-old male with an extensive past medical history including type 1 Question I have a patient with trigeminal neuralgia who was taking 1600 mg of gabapentin and had serious elevations of liver function tests (aspartate transaminase 258 U/L, alanine transaminase Gabapentin-Induced Liver Toxicity Chahal, Japjot MD 1; Arif, Muhammad Osman MD 2; Achufusi, Ted George MD 1 Author Information Gabapentin use isn’t known to affect enzyme or bilirubin levels, but it may rarely cause an allergic reaction characterized by elevated eosinophil levels. This is a condition called eosinophilia, which may cause liver damage. High liver enzyme levels may indicate inflammation within the liver, which can be a sign of a medical condition like hepatitis or other conditions. Elevated liver enzymes might be found during routine blood testing and are usually mildly raised for a short time. Therapy with gabapentin is not associated with serum aminotransferase elevations, but several cases of clinically apparent liver High liver enzyme levels may indicate inflammation within the liver, which can be a sign of a medical condition like hepatitis or other conditions. Elevated liver enzymes might be found during routine blood testing and are usually mildly raised for a short time. Therapy with gabapentin is not associated with serum aminotransferase elevations, but several cases of clinically apparent liver Gabapentin doesn’t hurt the liver or kidneys in most cases. However, taking a safe gabapentin dose is important to prevent potential side effects. Gabapentin-Induced Liver ToxicityAm J Ther. 2022 Nov-Dec;29 (6):e751-e752. doi: 10.1097/MJT.0000000000001208. Epub 2020 Jun 5. These tests measure various enzymes and proteins produced by the liver, including alanine aminotransferase (ALT), aspartate aminotransferase (AST), alkaline phosphatase (ALP), bilirubin levels, and albumin levels. Elevated levels of these substances can indicate inflammation or damage to liver cells.
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