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The most common gabapentin (Neurontin) side effects are dizziness and drowsiness. This may affect your ability to drive or perform other activities. Other gabapentin side effects include edema (fluid buildup), weight gain, and eye problems, but these aren’t as common. Rare but serious gabapentin side effects include mood changes in children. Rare but serious side effects of gabapentin include: changes in memory, ability to concentrate, or personality. Gabapentin may cause breathing problems in people who use opioid pain medicines and those with chronic obstructive pulmonary disease (COPD). Older adults who take gabapentin also are at higher risk of breathing problems. Gabapentin extended-release tablets (Horizant) are used to treat restless legs syndrome (RLS; a condition that causes discomfort in the legs and a strong urge to move the legs, especially at night and when sitting or lying down). Gabapentin is in a class of medications called anticonvulsants. The U.S. Food and Drug Administration is warning that serious breathing problems can occur in patients who use gabapentin or pregabalin with opioids or other drugs that depress the central nervous system. The elderly and patients with lung problems are at higher risk when they use the drugs, according to an FDA drug safety communication. In 2019 the FDA issued a warning about the potential risks of respiratory depression in patients taking gabapentin or pregabalin in combination with central nervous system (CNS) depressants such as opioids, antidepressants, and benzodiazepines. ISSUE: FDA is warning that serious breathing difficulties may occur in patients using gabapentin (Neurontin, Gralise, Horizant) or pregabalin (Lyrica, Lyrica CR) who have respiratory risk factors. FDA is warning that serious breathing difficulties may occur when gabapentin (Neurontin, Gralise, Horizant) or pregabalin (Lyrica, Lyrica CR) is taken with other medicines that depress the central Despite those warnings, gabapentinoids — gabapentin in particular — are still being promoted as a treatment for all sorts of things, from dental pain to alcoholism to improving your sex life. Gabapentin has been pitched for so many different conditions that a drug company executive infamously called it “snake oil.” Gabapentin is FDA-approved for epilepsy and neuropathic pain caused by Serious side effects of Neurontin include weight gain, joint pain, motion sickness, blurred vision, and viral infection. Antiepileptic medications including gabapentin have been associated with an increased risk of suicidal thinking and behavior. Drug interactions of Neurontin include antacids and morphine. In 2019 the FDA issued a warning about the potential risks of respiratory depression in patients taking gabapentin or pregabalin in combination with central nervous system (CNS) depressants such as opioids, antidepressants, and benzodiazepines. Gabapentinoids (gabapentin and pregabalin) are widely used off-label for chronic pain, despite limited evidence of benefit (NEJM JW Gen Med May 1 2019 and JAMA Intern Med 2019; 179:695). Although their side effects include sedation and dizziness, widespread use of gabapentinoids suggests that clinicians perceive their potential harm to be minimal. Three studies published in 2024 challenge that Warnings Gabapentin can cause life-threatening breathing problems, especially if you already have a breathing disorder or if you use other medicines that can make you drowsy or slow your breathing. Seek emergency medical attention if you have very slow breathing. Some people have thoughts about suicide while taking seizure medicine. Gabapentin oral capsule can cause mild or serious side effects. The following list contains some of the key side effects that may occur while taking gabapentin. This list does not Stopping gabapentin suddenly can cause serious problems, including increasing your risk of seizures (if you are taking gabapentin to control seizures) or not improving your symptoms (if taking gabapentin for other indications). On December 19, 2019 FDA is warning that serious breathing difficulties may occur in patients using gabapentin (brand names Neurontin, Gralise, Horizant) or pregabalin (brand names Lyrica, Lyrica A commonly prescribed pain medication—gabapentin—often considered a safer alternative to opioids for those who suffer from low back pain is now under scrutiny after being linked to increased Medications affected by this warning include gabapentin (brand names: Neurontin and Gralise), gabapentin enacarbil (a gabapentin pro-drug under the brand name Horizant), pregabalin (brand names: Lyrica and Lyrica CR) and generic versions of gabapentinoids. While less common, the most serious side effects of gabapentin are described below, along with what to do if they happen. Severe Allergic Reactions. Gabapentin can cause allergic reactions, The FDA recently issued strong gabapentin warnings to doctors. It should not be prescribed with opioids if patients have respiratory problems like COPD. FDA is requiring new warnings about the risk of serious breathing difficulties that can lead to death in patients who use gabapentanoids with opioid pain medicines or other drugs that depress the
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