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Abstract Background Although gabapentin has been increasingly prescribed to older adults, the relationship between gabapentin and cognition/functional status is not well studied. Therefore, we aimed to examine the association of gabapentin use and cognitive/functional change in older adults. Methods Background: Gabapentin is increasingly prescribed to older adults, which raises concerns about its potential to cause neurocognitive changes. Therefore, we aimed to examine the association of gabapentin use with neurocognitive changes (i.e., cognitive decline, functional status decline, and motor Some studies suggest gabapentin reduces neurogenesis and synaptic plasticity in memory-related brain regions, though the precise mechanisms linking acute drug effects to long-term cognitive changes remain unclear. Chronic gabapentin exposure may also alter levels of gamma-aminobutyric acid (GABA), a crucial neurotransmitter for brain function. Apart from the well-described neuropsychiatric effects associated with gabapentinoids, cognitive impairment and dementia should be considered, especially in long-term treatment, patients with higher cDDDs, and younger patients. The long-term effects of gabapentin on dementia risk, particularly among patients with chronic pain, remain inadequately explored. Although previous studies have established a link between chronic pain and elevated risk of cognitive dysfunction, including dementia (Kao et al., 2021; Chen et al., 2023; Cao et al., 2019), the literature is sparse Regular gabapentin use appeared to increase risk of dementia by 29% and mild cognitive impairment (MCI) by 85%, researchers reported July 10 in the journal Regional Anesthesia & Pain Medicine. What’s more, the risk was more than doubled in people normally considered too young to suffer from brain aging, those 18 to 64, results show. Gabapentin has been increasingly prescribed to older adults for off-label indications, and accumulating evidence suggests potential for gabapentin misuse and related adverse events. However, the relation between gabapentin initiation and longer-term neurocognitive changes is not well understood. Long-term Gabapentin therapy for chronic pain is not associated with a differential risk of dementia across dosage levels, irrespective of age or gender. Further study into its potential cognitive impacts is essential. Frequent use of gabapentin for back pain may raise the risk of dementia by 29% and mild cognitive impairment by 85%, new study finds. While it helps many manage their symptoms, research suggests that prolonged or improper use might negatively impact brain function. **How Gabapentin Affects Cognition** Studies show gabapentin can impair memory, concentration, and problem-solving abilities. Short-term use may cause forgetfulness or difficulty focusing [1]. Here’s what you need to know: — ### **Physical Health Risks** – **Dependence and withdrawal**: Prolonged use can lead to physical dependence, meaning your body relies on the drug to function normally. Stopping suddenly may cause withdrawal symptoms like insomnia, nausea, sweating, anxiety, or even seizures [2] [5]. Research shows that patients with six or more prescriptions for gabapentin, commonly used to treat lower back pain, were 29% more likely to be diagnosed with dementia and 85% more likely to be diagnosed with mild cognitive impairment within 10 years of their initial pain diagnosis. Background: Gabapentin is increasingly prescribed to older adults, which raises concerns about its potential to cause neurocognitive changes. Therefore, we aimed to examine the association of gabapentin use with neurocognitive changes (i.e., Long-term Gabapentin therapy for chronic pain is not associated with a differential risk of dementia across dosage levels, irrespective of age or gender. Further study into its potential cognitive impacts is essential. While observational and not proof of causation, the study underscores the need to monitor patients on long-term gabapentin for signs of cognitive decline. Key facts: Adults prescribed gabapentin ≥6 times were 29% more likely to develop dementia and 85% more likely to develop mild cognitive impairment. Long-term use of PPIs could affect absorption of vitamin B12, which could also increase your risk for dementia. PPIs include: Omeprazole (Prilosec) Lansoprazole (Prevacid) Esomeprazole (Nexium) Pantoprazole (Protonix) 3. Pain medications Many people are aware that the use of opioid pain medications can lead to dependence, overdose, and even death. New data suggest an association between gabapentin for chronic back pain and increased risk of cognitive impairment, although experts urge caution in drawing any firm conclusions. Frequent use of common pain drug linked to increase in dementia and cognitive decline, study suggests. Receiving six or more prescriptions of the drug gabapentin for low back pain is associated with significantly increased risks of developing dementia and mild cognitive impairment (MCI)—29% and [4] Does Gabapentin Cause Short-Term Memory Loss? Scientists observe cases of short-term memory loss with gabapentin. It happens because of the following reasons: Higher dosage Combining gabapentin with other central nervous system (CNS) drugs Individual differences (age, health, genetics, etc) Prolonged use Initial use.
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