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An investigational nonhormonal drug, extended-release gabapentin, effectively improved sleep and reduced hot flashes in menopausal women. Insomnia related to nighttime awakenings is known to be more prevalent in women than men. Three cases are presented here of late premenopausal women experiencing frequent nighttime awakenings that responded well to bedtime treatment with gabapentin. The hypoestrogenism, resulting from ovarian failure promotes a series of negative consequences in relation to women’s health, like insomnia, anxiety, irritability, hot flashes, sleep-disordered breathing, qualitative alterations in the skin and hair. In addition, there is a modification in fat distribution, with more abdominal after menopause. The aim of this study was to systematically review the efficacy and tolerability of gabapentin in the treatment of sleep disturbance in patients with medical illness. PubMed was searched for randomized, double-blinded, placebo-controlled trials that Several studies have shown that gabapentin (Neurontin) at 600-2400 mg/day in divided doses is effective for treating hot flashes in menopausal women. Research presented at the annual meeting of the North American Menopause Society (NAMS) indicates that an investigational extended release (ER) formulation of gabapentin (Serada, Depomed) is effective for the treatment of hot flashes and sleep HRT is the current go-to treatment for menopausal hot flashes. Gabapentin offers non-hormonal relief and reduction in hot flashes and night sweats. The journey through menopause is unique for each woman, and so too should be the approach to managing its symptoms, including sleep disturbances. By combining medical interventions like gabapentin with holistic lifestyle changes and alternative therapies, many women can find relief from the sleep issues that often accompany this transitional Navigating menopause can be challenging, with symptoms like hot flashes, mood swings, and sleep disturbances affecting daily life. While hormone replacement therapy is a common treatment, some women seek alternatives. Gabapentin, traditionally used for nerve pain, has emerged as a promising option for managing menopausal symptoms. Various non-hormonal agents have been used for the treatment of hot flashes in women with menopause. Some studies have reported that gabapentin appears to be an effective and well-tolerated treatment modality. The aim of this study was to evaluate This study revealed that without consideration of the type of sleep outcomes, gabapentin was significantly superior to placebos for the treatment for sleep disorders secondary to RLS, neuropathic pain, alcohol dependence, hot flashes in menopause, fibromyalgia, phantom limb pain, HIV-associated sensory neuropathies, and bipolar disorder. The North American Menopause society and the American College of Obstetricians and Gynecologists recommend gabapentin as an option for managing hot flashes in women who are unwilling to take estrogen-containing supplements. Gabapentin is a medication you might have heard about for treating seizures or nerve pain, but it’s also gaining attention as a helpful option for women dealing with menopause symptoms—especially hot flashes and trouble sleeping. When women go through menopause, their bodies produce less estrogen. About 80% of postmenopausal women experience vasomotor symptoms, such as hot flashes and night sweats – symptoms that are associated with sleep disruption and can lead to fatigue and mood changes. Moreover, hot flashes can be embarrassing for women, NATIONAL HARBOR, MD. – Extended-release gabapentin at daily doses of either 1,200 mg or 1,800 mg significantly reduced the number and severity of hot flashes and significantly improved sleep problems, compared with a placebo, in postmenopausal women. Insomnia is one of the major complaints of menopausal women with advancing age and may be complexly related to a variety of causes. However, there is still a lack of standards on the general approach and treatment for insomnia in menopausal women. For persons who received gabapentin off-label for the management of a sleep disorder, were other hypnotics (i.e. sleep aids) first tested? If other hypnotics were trialed prior to gabapentin, mention the number that were tested and how gabapentin [subjectively] compared in terms of hypnotic efficacy and tolerability. Gabapentin may improve sleep quality in menopausal women with hot flashes. These results warrant further prospective investigation, with an emphasis on measuring subjective sleep quality and maintenance. Insomnia related to nighttime awakenings is known to be more prevalent in women than men. Three cases are presented here of late premenopausal women experiencing frequent nighttime awakenings that responded well to bedtime treatment with gabapentin. In Gabapentin is helpful in patients with a history of neuropathic pain issues, and when dosed before bedtime, can be an effective sleep aid. 10, 11 The most pertinent side effects of gabapentin to consider before initiation include dizziness or coordination difficulties (thus, possible increase in fall risk), edema, drowsiness, lethargy, weight
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