Purpose of Review This review summarizes the risks and benefits of gabapentinoids (gabapentin and pregabalin) for perioperative pain control and the controversies surrounding their use in a variety of settings. We review current literature with the goal of providing patient-centric and procedure-specific recommendations for the use of these medications. Recent Findings Gabapentinoids are among Consider the following when using gabapentinoids in the perioperative period The evidence supports the use of gabapentinoids in the perioperative period. A typical dose range for perioperative gabapentin is 200-300 mg and 25-50 mg for pregabalin. Given the opioid-sparing effect of gabapentinoids, lower doses of perioperative narcotics may be used. Effective postoperative pain management is crucial in the care of surgical patients. Opioids, which are commonly used in managing postoperative pain, have a potential for tolerance and addiction, along with sedating side effects. Gabapentin’s use as In recent years, there has been increased interest in using gabapentinoids (gabapentin and pregabalin) as part of multimodal medication plans or enhanced recovery after surgery protocols to mitigate several perioperative clinical challenges. Neurologic diseases are prevalent in patients undergoing invasive procedures; yet, no societal guidelines exist as to best practice in management of perioperative medications prescribed to treat these disorders. The Society for Perioperative Assessment and Quality Improvement tasked experts in internal medicine, anesthesiology, perioperative medicine, and neurology to provide evidence-based Conclusion: Gabapentin 600 mg administered 1 hr before laparoscopic abdominal surgery is as effective as gabapentin 900 mg for PONV control and VAS reduction of 24-hour postoperative pain scores with fewer side effects. On the other hand, gabapentin 300 mg did not demonstrate good control of PONV, or pain control compared to higher doses. Prescription of gabapentin and pregabalin in the perioperative period has become increasingly common, if not de rigueur. These gabapentinoids have become ubiquitous components of protocols for early recovery after surgery and multi-modal analgesia. Gabapentin, an anticonvulsant, recently has been suggested as an effective post-operative “analgesic” agent. The objective of the present study was to examine the analgesic effectiveness and opioid-sparing effects associated with the use of a single Abstract Purpose of review: This review summarizes the risks and benefits of gabapentinoids (gabapentin and pregabalin) for perioperative pain control and the controversies surrounding their use in a variety of settings. We review current literature with the goal of providing patient-centric and procedure-specific recommendations for the use of these medications. Gabapentin (1-aminomethyl-cyclohexaneacetic acid) is an amino acid that has the structure of the neurotransmitter γ-aminobutyric acid (GABA). It is a novel drug used for the treatment of postoperative pain with antihyperalgesic properties and a SUMMARY Gabapentin (NeurontinTM) has gained significant interest as part of a multi-modal pain management strategy for the control of acute pain. There has been considerable variation in both the dose and the regimen used in recent clinical trials. Most have relied on pre-operative dosing and have utilized a single dose of 300 to 1200 mg. Higher doses seem to show a decrease in postoperative SUMMARY Gabapentin (NeurontinTM) has gained significant interest as part of a multi-modal pain management strategy for the control of acute pain. There has been considerable variation in both the dose and the regimen used in recent clinical trials. Most have relied on pre-operative dosing and have utilized a single dose of 300 to 1200 mg. Higher doses seem to show a decrease in postoperative Ultimately, the decision regarding whether you can take Gabapentin before surgery rests on thorough discussions with your healthcare provider. They will consider various factors including your medical history, current health status, type of surgery planned, and potential interactions with anesthesia. Guideline for Preoperative Medication Management Purpose of Guideline: To provide guidance to physicians, advanced practice providers (APPs), pharmacists, and nurses regarding medication management in the preoperative setting. The search used the following subject headings and text terms: “gabapentin”, “Neurontin”, “postoperative care”, “postoperative period”, “perioperative care”, “surgery”, “pain treatment”, “analgesic” and “analgesia” (16). Bibliographies of included articles and published reviews were also searched. Reviewer comment: I think if we are going to administer pre‐op drugs the gabapentin dose needs to be considered in renal failure ‐ even celebrex dosing may need consideration and adjustment on a case by case basis. Preoperative Medication Lyrica, Gabapentin, Celebrex, and Tylenol Under the Enhanced Recovery After Surgery protocol, three medications are prescribed in combination, to be taken in advance of surgery. Treating pain preoperatively improves pain management after surgery. Amr, YM, Yousef, AA Evaluation of efficacy of the perioperative administration of Venlafaxine or gabapentin on acute and chronic postmastectomy pain. Clin J Pain. (2010). 26 381-5. Highlights Conclusion Preoperative oral gabapentin decreases postoperative pain, prolongs analgesia duration, and decreases total opioid consumption in patients undergoing anorectal surgeries. Limitations The study did not compare different doses of gabapentin to detect the exact amount that gives the maximum beneficial effects with the most negligible side effects. However, this may be a We need to unwind the automaticity of gabapentin use in the perioperative period. For example, in this study, 5 80% of gabapentin users received gabapentin on the day of surgery, suggesting that it was started prior to any patient report of pain, representing an opportunity to de-escalate gabapentin use for some patients.
Articles and news, personal stories, interviews with experts.
Photos from events, contest for the best costume, videos from master classes.
![]() | ![]() |
![]() | ![]() |
![]() | ![]() |
![]() | ![]() |
![]() | ![]() |
![]() | ![]() |